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Tytuł pozycji:

CD15 immunostaining improves placental diagnosis of fetal hypoxia.

Tytuł :
CD15 immunostaining improves placental diagnosis of fetal hypoxia.
Autorzy :
Seidmann L; Institute of Pathology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131, Mainz, Germany. Electronic address: .
Kamyshanskiy Y; Institute of Pathology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131, Mainz, Germany.
Wagner DC; Institute of Pathology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131, Mainz, Germany.
Zimmer S; Institute of Pathology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131, Mainz, Germany.
Roth W; Institute of Pathology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131, Mainz, Germany.
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Źródło :
Placenta [Placenta] 2021 Feb; Vol. 105, pp. 41-49. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: <2010- > : Amsterdam : Elsevier
Original Publication: London W.B. Saunders.
MeSH Terms :
Fetal Hypoxia/*diagnosis
Lewis X Antigen/*metabolism
Placenta/*metabolism
Pre-Eclampsia/*diagnosis
Adult ; Female ; Fetal Hypoxia/metabolism ; Humans ; Immunohistochemistry ; Infant, Newborn ; Pre-Eclampsia/metabolism ; Pregnancy ; Retrospective Studies
Contributed Indexing :
Keywords: CD15*; Endothelial progenitors*; Fetal hypoxia*; Gestational diabetes mellitus*; Placenta*; Preeclampsia*
Substance Nomenclature :
0 (Lewis X Antigen)
Entry Date(s) :
Date Created: 20210205 Date Completed: 20211207 Latest Revision: 20211214
Update Code :
20220301
DOI :
10.1016/j.placenta.2021.01.016
PMID :
33545630
Czasopismo naukowe
Introduction: Fetal hypoxic events with unclear predictive value are a common indication for placenta examination. We evaluated whether the use of CD15 immunostaining can improve the assessment of severity and duration of fetal hypoxia.
Methods: We compared placentas (37-42 gestational weeks) from stillborns/newborns with birth asphyxia (BA) and non-hypoxic newborns. Placental findings were studied in following groups: (1) acute BA (n = 11) due to placental abruption, (2) non-acute BA (n = 121) due to non-acute conditions, (3) non-BA (n = 46) in pregnancies with preeclampsia and gestational diabetes, and (4) controls (n = 30).
Results: A high expression of CD15 in feto-placental resistance vessels (FRVs) was present in non-acute BA (95.9%), but absent in acute BA, non-BA and controls (p < 0.0001). Furthermore, we found no causal relationship of high expression of CD15 in FRVs to coexisting placental conditions, including severity and mechanisms/patterns of placental injury, fetal erythroblastosis, and maternal conditions. According to a multivariate analysis, only a high expression of CD15 in FRVs was independently associated with severe non-acute fetal hypoxia ([OR] = 15.52; 95% [CI] = 5.92-40.67).
Discussion: We have defined a characteristic pattern of CD15 expression in FRVs that allows to interpret various clinical/placental conditions with respect to fetal hypoxia, with an improved predictability compared to conventional analyses. This approach represents a novel diagnostic strategy for placenta examination, which could indirectly assess severity and duration of intrauterine hypoxia in a heterogeneous population of newborns.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)

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