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Wyszukujesz frazę ""Aniline Compounds"" wg kryterium: Temat


Tytuł :
Development, validation and application of a liquid chromatography-tandem mass spectrometry method for the activity and inhibition of DPP-4.
Autorzy :
Bronsema KJ; ICON, Early Development Services Laboratory, Assen, TK, 9407, The Netherlands.
Lambert W; ICON, Early Development Services Laboratory, Assen, TK, 9407, The Netherlands.
Charmont S; Novartis Pharma AG, Biomarker Development, Basel, CH-4056, Switzerland.
Sangana R; Novartis Healthcare Private Limited, Hyderabad, 500081, India.
Trigt RV; ICON, Early Development Services Laboratory, Assen, TK, 9407, The Netherlands.
Valentin MA; Novartis Pharma AG, Biomarker Development, Basel, CH-4056, Switzerland.
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Źródło :
Bioanalysis [Bioanalysis] 2022 Mar; Vol. 14 (6), pp. 369-378. Date of Electronic Publication: 2022 Mar 07.
Typ publikacji :
Journal Article; Validation Study
MeSH Terms :
Aniline Compounds/*pharmacology
Dipeptidyl Peptidase 4/*metabolism
Dipeptidyl-Peptidase IV Inhibitors/*pharmacology
Aniline Compounds/chemical synthesis ; Aniline Compounds/chemistry ; Chromatography, Liquid ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Dipeptidyl-Peptidase IV Inhibitors/chemical synthesis ; Dipeptidyl-Peptidase IV Inhibitors/chemistry ; Humans ; Molecular Structure ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton.
Autorzy :
Hino T; Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan.
Saitoh T; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Nagumo Y; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Yamamoto N; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Kutsumura N; Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Irukayama-Tomobe Y; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Ishikawa Y; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Tanimura R; Pharmaceutical Research Laboratories, Toray Industries Inc., 10-1, Tebiro 6-choume, Kamakura, Kanagawa 248-8555, Japan.
Yanagisawa M; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; R&D Center for Frontiers of Mirai in Policy and Technology (F-MIRAI), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.
Nagase H; Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. Electronic address: .
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Mar 01; Vol. 59, pp. 128530. Date of Electronic Publication: 2022 Jan 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Aniline Compounds/*pharmacology
Benzamides/*pharmacology
Naphthalenes/*pharmacology
Orexin Receptors/*agonists
Aniline Compounds/chemical synthesis ; Aniline Compounds/chemistry ; Benzamides/chemical synthesis ; Benzamides/chemistry ; Dose-Response Relationship, Drug ; Humans ; Molecular Structure ; Naphthalenes/chemical synthesis ; Naphthalenes/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Probing Noncovalent Interactions in [3,3]Metaparacyclophanes.
Autorzy :
Jian J; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark.
Hammink R; Division of Immunotherapy, Oncode Institute, Radboud University Medical Center, Nijmegen, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands.; Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands.
Tinnemans P; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
Bickelhaupt FM; Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.; Department of Theoretical Chemistry, Amsterdam Center for Multiscale Modeling, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
McKenzie CJ; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark.
Poater J; ICREA, Passeig Lluís Companys 23, 08010 Barcelona, Spain.; Departament de Química Inorgànica i Orgànica & IQTCUB, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain.
Mecinović J; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2022 May 06; Vol. 87 (9), pp. 6087-6096. Date of Electronic Publication: 2022 Apr 26.
Typ publikacji :
Journal Article
MeSH Terms :
Aniline Compounds*
Phenols*
Crystallography, X-Ray ; Molecular Conformation ; Static Electricity
Czasopismo naukowe
Tytuł :
Clinicohematological, Mutagenic, and Oxidative Stress Induced by Pendimethalin in Freshwater Fish Bighead Carp ( Hypophthalmichthys nobilis ).
Autorzy :
Wang JQ; Institute of Modern Facility Fisheries, College of Biological and Agricultural Engineering, Weifang University, Weifang 261061, China.
Hussain R; Department of Pathology, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, 63100, Pakistan.
Ghaffar A; Department of Zoology, Faculty of Sciences, The Islamia University of Bahawalpur, 63100, Pakistan.
Afzal G; Department of Zoology, Faculty of Sciences, The Islamia University of Bahawalpur, 63100, Pakistan.
Saad AQ; Department of Zoology, Faculty of Sciences, The Islamia University of Bahawalpur, 63100, Pakistan.
Ahmad N; Department of Zoology, Faculty of Sciences, The Islamia University of Bahawalpur, 63100, Pakistan.
Nazir U; Department of Zoology, Faculty of Sciences, The Islamia University of Bahawalpur, 63100, Pakistan.
Ahmad HI; Department of Animal Breeding and Genetics, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Hussain T; Animal Sciences Division, Nuclear Institute for Agriculture and Biology College, Pakistan; Institute of Engineering and Applied Sciences (NIAB-C, PIEAS), Jhang Road, Faisalabad 38000, Pakistan.
Khan A; Shandong Vocational Animal Science and Veterinary College, Weifang 261061, China.; Faculty of Veterinary Science, University of Agriculture, Faisalabad 38040, Pakistan.
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Źródło :
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2022 Apr 28; Vol. 2022, pp. 2093822. Date of Electronic Publication: 2022 Apr 28 (Print Publication: 2022).
Typ publikacji :
Journal Article; Randomized Controlled Trial, Veterinary
MeSH Terms :
Aniline Compounds*/toxicity
Carps*/metabolism
Herbicides*/toxicity
Water Pollutants, Chemical*/toxicity
Animals ; Atrophy ; Catalase/metabolism ; Ecosystem ; Fresh Water ; Liver/metabolism ; Mutagens ; Necrosis/metabolism ; Oxidative Stress ; Superoxide Dismutase/metabolism
Czasopismo naukowe
Tytuł :
Alternating Current Electrolysis Enabled Formal C-O/O-H Cross-Metathesis of 4-Alkoxy Anilines with Alcohols.
Autorzy :
Wang D; National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022, P. R. China.
Jiang T; National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022, P. R. China.
Wan H; National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022, P. R. China.
Chen Z; National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022, P. R. China.
Qi J; National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022, P. R. China.
Yang A; National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022, P. R. China.
Huang Z; College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, P. R. China.
Yuan Y; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China.
Lei A; National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang, 330022, P. R. China.; College of Chemistry and Molecular Sciences, The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, 430072, P. R. China.
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Źródło :
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2022 Apr 25; Vol. 61 (18), pp. e202201543. Date of Electronic Publication: 2022 Mar 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alcohols*/chemistry
Aniline Compounds*
Alkenes/chemistry ; Electrolysis
Czasopismo naukowe
Tytuł :
The potential skin-lightening candidate, senolytic drug ABT263, for photoageing pigmentation.
Autorzy :
Park JH; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea.; Institution of Inflamm-aging Translational Research Center, Ajou University School of Medicine, Suwon, Korea.
Yoon JE; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea.; Institution of Inflamm-aging Translational Research Center, Ajou University School of Medicine, Suwon, Korea.
Kim YH; Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
Kim Y; Institution of Inflamm-aging Translational Research Center, Ajou University School of Medicine, Suwon, Korea.; Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
Park TJ; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea.; Institution of Inflamm-aging Translational Research Center, Ajou University School of Medicine, Suwon, Korea.
Kang HY; Institution of Inflamm-aging Translational Research Center, Ajou University School of Medicine, Suwon, Korea.; Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
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Źródło :
The British journal of dermatology [Br J Dermatol] 2022 Apr; Vol. 186 (4), pp. 740-742. Date of Electronic Publication: 2022 Jan 20.
Typ publikacji :
Letter
MeSH Terms :
Aniline Compounds*
Sulfonamides*
Humans ; Pigmentation ; Skin ; Skin Pigmentation
Opinia redakcyjna
Tytuł :
Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin.
Autorzy :
Ahmadinejad F; Department of Human and Molecular Genetics, School of Medicine (F.A.), Philips Institute for Oral Health Research, School of Dentistry (T.B., E.B., A.C.F., H.H.), Cancer Mouse Models Core (B.H., J.K.), and Department of Pharmacology and Toxicology, School of Medicine (D.A.G.), Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia; and AbbVie, North Chicago, Illinois (A.J.S., J.D.L.).
Bos T; Department of Human and Molecular Genetics, School of Medicine (F.A.), Philips Institute for Oral Health Research, School of Dentistry (T.B., E.B., A.C.F., H.H.), Cancer Mouse Models Core (B.H., J.K.), and Department of Pharmacology and Toxicology, School of Medicine (D.A.G.), Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia; and AbbVie, North Chicago, Illinois (A.J.S., J.D.L.).
Hu B; Department of Human and Molecular Genetics, School of Medicine (F.A.), Philips Institute for Oral Health Research, School of Dentistry (T.B., E.B., A.C.F., H.H.), Cancer Mouse Models Core (B.H., J.K.), and Department of Pharmacology and Toxicology, School of Medicine (D.A.G.), Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia; and AbbVie, North Chicago, Illinois (A.J.S., J.D.L.).
Britt E; Department of Human and Molecular Genetics, School of Medicine (F.A.), Philips Institute for Oral Health Research, School of Dentistry (T.B., E.B., A.C.F., H.H.), Cancer Mouse Models Core (B.H., J.K.), and Department of Pharmacology and Toxicology, School of Medicine (D.A.G.), Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia; and AbbVie, North Chicago, Illinois (A.J.S., J.D.L.).
Koblinski J; Department of Human and Molecular Genetics, School of Medicine (F.A.), Philips Institute for Oral Health Research, School of Dentistry (T.B., E.B., A.C.F., H.H.), Cancer Mouse Models Core (B.H., J.K.), and Department of Pharmacology and Toxicology, School of Medicine (D.A.G.), Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia; and AbbVie, North Chicago, Illinois (A.J.S., J.D.L.).
Souers AJ; Department of Human and Molecular Genetics, School of Medicine (F.A.), Philips Institute for Oral Health Research, School of Dentistry (T.B., E.B., A.C.F., H.H.), Cancer Mouse Models Core (B.H., J.K.), and Department of Pharmacology and Toxicology, School of Medicine (D.A.G.), Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia; and AbbVie, North Chicago, Illinois (A.J.S., J.D.L.).
Leverson JD; Department of Human and Molecular Genetics, School of Medicine (F.A.), Philips Institute for Oral Health Research, School of Dentistry (T.B., E.B., A.C.F., H.H.), Cancer Mouse Models Core (B.H., J.K.), and Department of Pharmacology and Toxicology, School of Medicine (D.A.G.), Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia; and AbbVie, North Chicago, Illinois (A.J.S., J.D.L.).
Faber AC; Department of Human and Molecular Genetics, School of Medicine (F.A.), Philips Institute for Oral Health Research, School of Dentistry (T.B., E.B., A.C.F., H.H.), Cancer Mouse Models Core (B.H., J.K.), and Department of Pharmacology and Toxicology, School of Medicine (D.A.G.), Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia; and AbbVie, North Chicago, Illinois (A.J.S., J.D.L.).
Gewirtz DA; Department of Human and Molecular Genetics, School of Medicine (F.A.), Philips Institute for Oral Health Research, School of Dentistry (T.B., E.B., A.C.F., H.H.), Cancer Mouse Models Core (B.H., J.K.), and Department of Pharmacology and Toxicology, School of Medicine (D.A.G.), Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia; and AbbVie, North Chicago, Illinois (A.J.S., J.D.L.) .
Harada H; Department of Human and Molecular Genetics, School of Medicine (F.A.), Philips Institute for Oral Health Research, School of Dentistry (T.B., E.B., A.C.F., H.H.), Cancer Mouse Models Core (B.H., J.K.), and Department of Pharmacology and Toxicology, School of Medicine (D.A.G.), Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia; and AbbVie, North Chicago, Illinois (A.J.S., J.D.L.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2022 Mar; Vol. 101 (3), pp. 168-180. Date of Electronic Publication: 2021 Dec 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aniline Compounds/*administration & dosage
Antineoplastic Agents/*administration & dosage
Cellular Senescence/*drug effects
Cisplatin/*administration & dosage
Head and Neck Neoplasms/*drug therapy
Sulfonamides/*administration & dosage
Tumor Suppressor Protein p53/*genetics
bcl-2-Associated X Protein/*genetics
Aniline Compounds/pharmacology ; Animals ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cisplatin/pharmacology ; Drug Synergism ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Humans ; Mice ; Mutation ; Sulfonamides/pharmacology ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Validation of a robust and rapid liquid chromatography tandem mass spectrometric method for the quantitative analysis of navitoclax.
Autorzy :
Scott SC; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, USA.
Anders NM; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, USA.
He P; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, USA.
Hemingway A; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, USA.
Gore SD; IDB/CTEP/NCI, National Cancer Institute, Rockville, Maryland, USA.
Hann CL; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, USA.
Rudek MA; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, USA.; Division of Clinical Pharmacology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2022 Mar; Vol. 36 (3), pp. e5289. Date of Electronic Publication: 2022 Jan 07.
Typ publikacji :
Journal Article
MeSH Terms :
Aniline Compounds*
Sulfonamides*
Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid/methods ; Humans ; Reproducibility of Results ; Tandem Mass Spectrometry/methods
Czasopismo naukowe
Tytuł :
Bemcentinib and Gilteritinib Inhibit Cell Growth and Impair the Endo-Lysosomal and Autophagy Systems in an AXL-Independent Manner.
Autorzy :
Zdżalik-Bielecka D; Laboratory of Cell Biology, International Institute of Molecular and Cell Biology, Warsaw, Poland.
Kozik K; Laboratory of Cell Biology, International Institute of Molecular and Cell Biology, Warsaw, Poland.
Poświata A; Laboratory of Cell Biology, International Institute of Molecular and Cell Biology, Warsaw, Poland.
Jastrzębski K; Laboratory of Cell Biology, International Institute of Molecular and Cell Biology, Warsaw, Poland.
Jakubik M; Laboratory of Cell Biology, International Institute of Molecular and Cell Biology, Warsaw, Poland.
Miączyńska M; Laboratory of Cell Biology, International Institute of Molecular and Cell Biology, Warsaw, Poland.
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Źródło :
Molecular cancer research : MCR [Mol Cancer Res] 2022 Mar 01; Vol. 20 (3), pp. 446-455.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aniline Compounds/*therapeutic use
Benzocycloheptenes/*therapeutic use
Lysosomes/*drug effects
Protein Kinase Inhibitors/*therapeutic use
Proto-Oncogene Proteins/*antagonists & inhibitors
Pyrazines/*therapeutic use
Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors
Triazoles/*therapeutic use
Aniline Compounds/pharmacology ; Autophagy ; Benzocycloheptenes/pharmacology ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Protein Kinase Inhibitors/pharmacology ; Pyrazines/pharmacology ; Signal Transduction ; Transfection ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
Discovery of DS-3801b, a non-macrolide GPR38 agonist with N-methylanilide structure.
Autorzy :
Toda N; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. Electronic address: .
Shida T; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
Takano R; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
Katagiri T; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
Hirouchi M; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
Abe M; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
Soma K; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
Nakagami Y; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
Yamazaki M; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
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Źródło :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Mar 01; Vol. 59, pp. 128554. Date of Electronic Publication: 2022 Jan 18.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Aniline Compounds/*pharmacology
Cyclohexanes/*pharmacology
Gastrointestinal Agents/*pharmacology
Gastroparesis/*drug therapy
Piperazines/*pharmacology
Receptors, G-Protein-Coupled/*agonists
Aniline Compounds/chemistry ; Animals ; Cyclohexanes/chemical synthesis ; Cyclohexanes/chemistry ; Dose-Response Relationship, Drug ; Gastrointestinal Agents/chemical synthesis ; Gastrointestinal Agents/chemistry ; Gastroparesis/metabolism ; Humans ; Molecular Structure ; Piperazines/chemical synthesis ; Piperazines/chemistry ; Rabbits ; Receptors, G-Protein-Coupled/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
INSIGHT 2: a phase II study of tepotinib plus osimertinib in MET -amplified NSCLC and first-line osimertinib resistance.
Autorzy :
F Smit E; Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Dooms C; Department of Respiratory Diseases & Respiratory Oncology Unit, University Hospitals Leuven, Leuven, Belgium.
Raskin J; Department of Pulmonology & Thoracic Oncology, Antwerp University Hospital (UZA), Edegem, Belgium.
Nadal E; Department of Medical Oncology, Catalan Institute of Oncology, L'Hospitalet, Barcelona, Spain.
Tho LM; Department of Oncology, Pantai Hospital, Kuala Lumpur, Malaysia.
Le X; Department of Thoracic Head & Neck Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Mazieres J; CHU de Toulouse, Institut Universitaire du Cancer, Toulouse, France.
S Hin H; Hospital Tengku Ampuan Afzan, Pahang, Malaysia.
Morise M; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
W Zhu V; University of California Irvine, Chao Family Comprehensive Cancer Center, Orange, CA, USA.
Tan D; Division of Medical Oncology, National Cancer Centre Singapore, Singapore.
H Holmberg K; EMD Serono Research & Development Institute, Inc., MA, USA, an affiliate of Merck KGaA.
Ellers-Lenz B; Department of Biostatistics, Merck Healthcare KGaA, Darmstadt, Germany.
Adrian S; Global Clinical Development, Merck Healthcare KGaA, Darmstadt, Germany.
Brutlach S; Late Stage Development Operations, Merck Healthcare KGaA, Darmstadt, Germany.
Schumacher KM; Global Clinical Development, Merck Healthcare KGaA, Darmstadt, Germany.
Karachaliou N; Global Clinical Development, Merck Healthcare KGaA, Darmstadt, Germany.
Wu YL; Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China.
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Źródło :
Future oncology (London, England) [Future Oncol] 2022 Mar; Vol. 18 (9), pp. 1039-1054. Date of Electronic Publication: 2021 Dec 17.
Typ publikacji :
Clinical Trial Protocol; Clinical Trial, Phase II; Journal Article; Multicenter Study
MeSH Terms :
Drug Resistance, Neoplasm*
Neoplasm Metastasis*
Acrylamides/*therapeutic use
Aniline Compounds/*therapeutic use
Antineoplastic Agents/*therapeutic use
Carcinoma, Non-Small-Cell Lung/*drug therapy
Lung Neoplasms/*drug therapy
Piperidines/*therapeutic use
Pyridazines/*therapeutic use
Pyrimidines/*therapeutic use
Acrylamides/administration & dosage ; Aniline Compounds/administration & dosage ; Antineoplastic Agents/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/secondary ; Humans ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Piperidines/administration & dosage ; Progression-Free Survival ; Pyridazines/administration & dosage ; Pyrimidines/administration & dosage
Czasopismo naukowe
Tytuł :
Discovery of highly potent and selective EGFR TKIs against NSCLC based on molecular dynamic simulation.
Autorzy :
Yang T; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
Zhang W; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
Cao S; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
Sun S; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
Cai X; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
Xu L; Institute of Bioinformatics and Medical Engineering, Jiangsu University of Technology, Changzhou, China.
Li P; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China. Electronic address: .
Zheng Z; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China. Electronic address: .
Li S; Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2022 Jan 15; Vol. 228, pp. 113984. Date of Electronic Publication: 2021 Nov 11.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Dynamics Simulation*
Acrylamides/*pharmacology
Aniline Compounds/*pharmacology
Antineoplastic Agents/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
Lung Neoplasms/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Acrylamides/chemical synthesis ; Acrylamides/chemistry ; Aniline Compounds/chemical synthesis ; Aniline Compounds/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Discovery ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Design and Evaluation of a Novel Peptide-Drug Conjugate Covalently Targeting SARS-CoV-2 Papain-like Protease.
Autorzy :
Liu N; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.; Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China.
Zhang Y; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
Lei Y; Institute for Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518032, China.
Wang R; Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China.
Zhan M; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
Liu J; Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China.
An Y; Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China.
Zhou Y; Institute for Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518032, China.
Zhan J; Institute for Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518032, China.
Yin F; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.; Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China.
Li Z; State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.; Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2022 Jan 13; Vol. 65 (1), pp. 876-884. Date of Electronic Publication: 2022 Jan 04.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Aniline Compounds/*chemistry
Antiviral Agents/*metabolism
Benzamides/*chemistry
Coronavirus Papain-Like Proteases/*metabolism
Naphthalenes/*chemistry
Peptides/*chemistry
SARS-CoV-2/*enzymology
Aniline Compounds/metabolism ; Aniline Compounds/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Benzamides/metabolism ; Benzamides/pharmacology ; COVID-19/drug therapy ; COVID-19/pathology ; COVID-19/virology ; Cell Line ; Cell Survival/drug effects ; Coronavirus Papain-Like Proteases/chemistry ; Cytokines/chemistry ; Drug Evaluation, Preclinical ; Humans ; Inhibitory Concentration 50 ; Naphthalenes/metabolism ; Naphthalenes/pharmacology ; SARS-CoV-2/isolation & purification ; Ubiquitins/chemistry
Czasopismo naukowe
Tytuł :
Raman spectroelectrochemical study of poly(N-methylaniline) at UV, blue, red, and NIR laser line excitations in solutions of different pH.
Autorzy :
Mažeikienė R; Department of Organic Chemistry, Center for Physical Sciences and Technology (FTMC), Sauletekio av. 3, LT-10257 Vilnius, Lithuania.
Niaura G; Department of Organic Chemistry, Center for Physical Sciences and Technology (FTMC), Sauletekio av. 3, LT-10257 Vilnius, Lithuania.
Malinauskas A; Department of Organic Chemistry, Center for Physical Sciences and Technology (FTMC), Sauletekio av. 3, LT-10257 Vilnius, Lithuania. Electronic address: .
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Źródło :
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2022 Jun 05; Vol. 274, pp. 121109. Date of Electronic Publication: 2022 Mar 09.
Typ publikacji :
Journal Article
MeSH Terms :
Aniline Compounds*
Spectrum Analysis, Raman*
Hydrogen-Ion Concentration ; Lasers
Czasopismo naukowe
Tytuł :
Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands.
Autorzy :
Bian J; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Liu YQ; Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
He J; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Lin X; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Qiu CY; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Yu WB; Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Shen Y; Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhu ZY; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Ye DY; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China. Electronic address: .
Wang J; Department of Neurology and National Research Center for Aging and Medicine & National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address: .
Chu Y; Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Dec 15; Vol. 226, pp. 113887. Date of Electronic Publication: 2021 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Discovery*
Aniline Compounds/*pharmacology
Parkinson Disease/*drug therapy
alpha-Synuclein/*antagonists & inhibitors
Aniline Compounds/chemical synthesis ; Aniline Compounds/chemistry ; Animals ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Humans ; Ligands ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Molecular Structure ; Parkinson Disease/diagnosis ; Parkinson Disease/metabolism ; Protein Aggregates/drug effects ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; alpha-Synuclein/metabolism
Czasopismo naukowe
Tytuł :
Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity.
Autorzy :
Ashton TD; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Ngo A; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Favuzza P; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Bullen HE; Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, 3004, Australia; Monash University, Clayton, Victoria 3800, Australia.
Gancheva MR; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, Australia.
Romeo O; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, Australia.
Parkyn Schneider M; Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, 3004, Australia; Monash University, Clayton, Victoria 3800, Australia.
Nguyen N; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Steel RWJ; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Duffy S; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia.
Lowes KN; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Sabroux HJ; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Avery VM; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia.
Boddey JA; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Wilson DW; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, Australia.
Cowman AF; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Gilson PR; Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, 3004, Australia; Monash University, Clayton, Victoria 3800, Australia.
Sleebs BE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Dec; Vol. 117, pp. 105359. Date of Electronic Publication: 2021 Sep 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aniline Compounds/*chemistry
Aniline Compounds/*pharmacology
Antimalarials/*chemistry
Antimalarials/*pharmacology
Malaria/*drug therapy
Plasmodium/*drug effects
Quinazolines/*chemistry
Quinazolines/*pharmacology
Amination ; Aniline Compounds/therapeutic use ; Animals ; Antimalarials/therapeutic use ; Female ; Humans ; Malaria/parasitology ; Mice ; Plasmodium/physiology ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/physiology ; Quinazolines/therapeutic use
Czasopismo naukowe
Tytuł :
Carcinomatosis under control by osimertinib in EGFR and TP53 mutated lung adenocarcinoma.
Autorzy :
Provenzano L; Medical Oncology Department 1, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Cuccarini V; Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Platania M; Medical Oncology Department 1, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Canziani L; Medical Oncology Department 1, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Spagnoletti A; Medical Oncology Department 1, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Doniselli FM; Neuroradiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Eoli M; Molecular Neuro-oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Prelaj A; Medical Oncology Department 1, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.; Department of Electronics, Information, and Bioengineering, Polytechnic University of Milan, Milano, Milan, Italy.
Anghileri E; Molecular Neuro-oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
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Źródło :
Tumori [Tumori] 2021 Dec; Vol. 107 (6), pp. NP136-NP140. Date of Electronic Publication: 2021 Nov 02.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Mutation*
Acrylamides/*therapeutic use
Aniline Compounds/*therapeutic use
Carcinoma/*drug therapy
Carcinoma/*genetics
Carcinoma, Non-Small-Cell Lung/*drug therapy
Carcinoma, Non-Small-Cell Lung/*genetics
Tumor Suppressor Protein p53/*genetics
Acrylamides/administration & dosage ; Acrylamides/adverse effects ; Aniline Compounds/administration & dosage ; Aniline Compounds/adverse effects ; Biopsy ; Carcinoma/diagnosis ; Carcinoma, Non-Small-Cell Lung/diagnosis ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Female ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; Symptom Assessment ; Tomography, X-Ray Computed ; Treatment Outcome ; Tumor Suppressor Protein p53/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Fingerprint loss during combination therapy using osimertinib and anlotinib: A case report.
Autorzy :
Xie L; Cancer Institute, Xinqiao Hospital, Army Medical University, Chongqing, China.
Feng Y; Cancer Institute, Xinqiao Hospital, Army Medical University, Chongqing, China.
Sun J; Cancer Institute, Xinqiao Hospital, Army Medical University, Chongqing, China.
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Źródło :
Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2022 Feb; Vol. 47 (2), pp. 248-250. Date of Electronic Publication: 2021 Jul 08.
Typ publikacji :
Case Reports
MeSH Terms :
Dermatoglyphics*
Acrylamides/*adverse effects
Adenocarcinoma of Lung/*drug therapy
Aniline Compounds/*adverse effects
Antineoplastic Agents/*adverse effects
Indoles/*adverse effects
Lung Neoplasms/*drug therapy
Quinolines/*adverse effects
Acrylamides/therapeutic use ; Aniline Compounds/therapeutic use ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; ErbB Receptors/antagonists & inhibitors ; Humans ; Indoles/therapeutic use ; Male ; Middle Aged ; Protein Kinase Inhibitors/therapeutic use ; Quinolines/therapeutic use
Raport

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