Wyszukujesz frazę ""Keul, Marina"" wg kryterium: Autor
- Tytuł :
- Overcoming EGFR-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors
- Autorzy :
- Źródło :
- Nature Communications. 9(1)
-
Czasopismo naukowe
- Tytuł :
- Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S† †Electronic supplementary information (ESI) available. CCDC 1876852. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c9sc03445e
- Autorzy :
- Temat :
- Chemistry
- Źródło :
- Chemical Science
- Dostęp URL :
-
https://explore.openaire.eu/search/publication?articleId=pmid________::869a06718e2ccc9b2de2349a78f94959
http://europepmc.org/articles/PMC6886544
- Informacja :
- Dostęp do tej pozycji wymaga zalogowania się.
-
Czasopismo naukowe
- Tytuł :
- Lektion gelernt? Die molekularen Grundlagen von Kinase‐gerichteten Therapien und Wirkstoffresistenz im nicht‐kleinzelligen Lungenkrebs.
- Autorzy :
- Źródło :
- Angewandte Chemie. 2/23/2018, Vol. 130 Issue 9, p2329-2335. 7p.
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Czasopismo naukowe
- Tytuł :
- Inhibition of Osimertinib-Resistant Epidermal Growth Factor Receptor EGFR-T790M/C797S
- Autorzy :
- Temat :
-
General Chemistry
Drug resistance
Cancer research
Cancer
medicine.disease
medicine
Western blot
medicine.diagnostic_test
Epidermal growth factor receptor
biology.protein
biology
Osimertinib
Kinase
Receptor–ligand kinetics
Chemistry
T790M
respiratory tract diseases - Źródło :
- Chemical science, 10:10789
- Dostęp URL :
- https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b413a543f72bc1b1c20826ee3535b24
- Tytuł :
- Etablierung von biochemischen und strukturbasierten Systemen zur Charakterisierung wirkstoffresistenter EGFR-Mutanten
- Autorzy :
- Temat :
-
Präzisionsmedizin
NSCLC
EGFR
Kovalente EGFR-Inhibitoren
Biomarker - Opis pliku :
- application/pdf
- Dostęp URL :
-
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c415e775ae8341a6bfea5fb707bc41
http://hdl.handle.net/2003/39178
- Tytuł :
- Targeting Her2-insYVMA with Covalent InhibitorsA Focused Compound Screening and Structure-Based Design Approach.
- Autorzy :
- Źródło :
- Journal of Medicinal Chemistry; 10/22/2020, Vol. 63 Issue 20, p11725-11755, 31p
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Czasopismo naukowe
- Tytuł :
- RASPELD to Perform High-End Screening in an Academic Environment toward the Development of Cancer Therapeutics
- Autorzy :
- Temat :
-
Organic Chemistry
General Pharmacology, Toxicology and Pharmaceutics
Molecular Medicine
Drug Discovery
Biochemistry
Pharmacology
Graduate students
Cancer
medicine.disease
medicine
Computational biology
Epidermal growth factor receptor
biology.protein
biology
Computer science
Drug discovery
Regulator
Initial screen - Dostęp URL :
- https://explore.openaire.eu/search/publication?articleId=doi_________::34b3e3f0dc58deff4b4b1713c3601377
- Tytuł :
- Lessons To Be Learned: The Molecular Basis of Kinase-Targeted Therapies and Drug Resistance in Non-Small Cell Lung Cancer
- Autorzy :
- Temat :
-
General Chemistry
Catalysis
Drug resistance
Molecular targets
Non small cell
Precision medicine
Lung cancer
medicine.disease
medicine
Bioinformatics
Cancer
Targeted therapy
medicine.medical_treatment
business.industry
business
Biomarker (medicine) - Dostęp URL :
- https://explore.openaire.eu/search/publication?articleId=doi_________::d841377a06866ad3fa4c44301b9cfe8f
- Tytuł :
- Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site
- Autorzy :
- Temat :
-
Drug Discovery
Molecular Medicine
T790M
EGFR inhibitors
In vivo
Pharmacology
Binding site
Structure–activity relationship
Chemistry
Mutant
Gefitinib
medicine.drug
medicine
Epidermal growth factor receptor
biology.protein
biology - Dostęp URL :
- https://explore.openaire.eu/search/publication?articleId=doi_________::10fe6ad3d51c05fe5d26f5fbab25d1ee
- Tytuł :
- Characterization of Covalent-Reversible EGFR Inhibitors
- Autorzy :
- Temat :
-
General Chemical Engineering
General Chemistry
EGFR inhibitors
Kinase
Receptor tyrosine kinase
biology.protein
biology
Special class
Chemistry
Research groups
Stereochemistry
Covalent bond
Residence time
Article
lcsh:Chemistry
lcsh:QD1-999 - Źródło :
-
ACS Omega
ACS Omega, Vol 2, Iss 4, Pp 1563-1575 (2017) - Dostęp URL :
- https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7b3c21099076b17edc87b52aa8edb3
- Tytuł :
- Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor
- Autorzy :
- Temat :
-
Drug Discovery
Molecular Medicine
Phenotypic screening
Receptor–ligand kinetics
Indazole
chemistry.chemical_compound
chemistry
T790M
Molecular biology
Kinase
Epidermal growth factor receptor
biology.protein
biology
Mutant
Western blot
medicine.diagnostic_test
medicine
Cancer research
respiratory tract diseases - Dostęp URL :
- https://explore.openaire.eu/search/publication?articleId=doi_________::564158803e9ac4bea9d78338cb602b3b
- Tytuł :
- Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR
- Autorzy :
- Temat :
-
General Chemistry
Catalysis
Cancer
medicine.disease
medicine
Chemistry
EGFR inhibitors
Lung cancer
Drug resistance
Biochemistry
Drug discovery
Receptor tyrosine kinase
biology.protein
biology
Mutation
medicine.disease_cause
Transferase - Dostęp URL :
- https://explore.openaire.eu/search/publication?articleId=doi_________::7ec6440706f8bc62bbc7c27b47148507
- Tytuł :
- Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach
- Autorzy :
- Temat :
-
Drug Discovery
Molecular Medicine
Mutation
medicine.disease_cause
medicine
Transferase
Chemistry
Phenotype
Cancer
medicine.disease
Epidermal growth factor receptor
biology.protein
biology
Cancer research
Structure–activity relationship
EGFR inhibitors
Receptor tyrosine kinase
Biochemistry - Dostęp URL :
- https://explore.openaire.eu/search/publication?articleId=doi_________::ed290f49315f3c786973b95298a35753