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Tytuł :
Induction of DR5-Dependent Apoptosis by PGA 2 through ATF4-CHOP Pathway.
Autorzy :
Park KM; Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Park JY; Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Pyo J; Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Lee SY; Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Cancer Evolution Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Kim HS; Department of Biomedicine and Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.; Cancer Evolution Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2022 Jun 13; Vol. 27 (12). Date of Electronic Publication: 2022 Jun 13.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*/genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
Activating Transcription Factor 4/genetics ; Activating Transcription Factor 4/metabolism ; Apoptosis ; Cell Line, Tumor ; HCT116 Cells ; Humans ; Prostaglandins A ; RNA, Messenger ; TNF-Related Apoptosis-Inducing Ligand/metabolism ; Transcription Factor CHOP/genetics ; Transcription Factor CHOP/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy.
Autorzy :
Aboelella NS; Georgia Cancer Center, Augusta University, Augusta, Georgia, USA.
Brandle C; Georgia Cancer Center, Augusta University, Augusta, Georgia, USA.
Okoko O; Georgia Cancer Center, Augusta University, Augusta, Georgia, USA.
Gazi MY; Georgia Cancer Center, Augusta University, Augusta, Georgia, USA.
Ding ZC; Georgia Cancer Center, Augusta University, Augusta, Georgia, USA.
Xu H; Division of Biostatistics & Data Science, Department of Population Health Sciences, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Gorman G; McWhorter School of Pharmacy, Samford University, Birmingham, Alabama, USA.
Bollag R; Georgia Cancer Center, Augusta University, Augusta, Georgia, USA.; Department of Pathology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Davila ML; Blood and Marrow Transplant & Cellular Immunotherapy Department, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Bryan LJ; Georgia Cancer Center, Augusta University, Augusta, Georgia, USA.; Department of Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Munn DH; Georgia Cancer Center, Augusta University, Augusta, Georgia, USA.; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Piazza GA; Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, Alabama, USA.
Zhou G; Georgia Cancer Center, Augusta University, Augusta, Georgia, USA .; Department of Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
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Źródło :
Journal for immunotherapy of cancer [J Immunother Cancer] 2022 Jul; Vol. 10 (7).
Typ publikacji :
Journal Article
MeSH Terms :
Indomethacin*/pharmacology
Receptors, TNF-Related Apoptosis-Inducing Ligand*
Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Cell- and Tissue-Based Therapy ; Humans ; Mice ; Neoplasm Recurrence, Local ; Oxidative Stress ; TNF-Related Apoptosis-Inducing Ligand
Czasopismo naukowe
Tytuł :
Targeting the apoptosis pathway to treat tumours of the paediatric nervous system.
Autorzy :
Fitzgerald MC; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland.; National Children's Research Centre at Children's Health Ireland at Crumlin, Dublin, D12 N512, Ireland.
O'Halloran PJ; National Children's Research Centre at Children's Health Ireland at Crumlin, Dublin, D12 N512, Ireland.; Department of Neurosurgery, Queen Elizabeth Hospital, Birmingham, UK.
Connolly NMC; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland.
Murphy BM; Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland. .; National Children's Research Centre at Children's Health Ireland at Crumlin, Dublin, D12 N512, Ireland. .; Centre for Systems Medicine, Royal College of Surgeons in Ireland, 31A York Street, Dublin, D02 YN77, Ireland. .
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Źródło :
Cell death & disease [Cell Death Dis] 2022 May 14; Vol. 13 (5), pp. 460. Date of Electronic Publication: 2022 May 14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Neoplasms*/drug therapy
Neoplasms*/genetics
Neoplasms*/pathology
TNF-Related Apoptosis-Inducing Ligand*/pharmacology
Apoptosis ; Child ; Humans ; Nervous System/metabolism ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism
Czasopismo naukowe
Tytuł :
Understanding of cell death induced by the constituents of Taxus yunnanensis wood.
Autorzy :
Akao Y; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan. .
Terazawa R; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan.
Sugito N; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan.
Heishima K; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan.
Morikawa K; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan.
Ito Y; Department of General and Gastroenterological Surgery, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Narui R; Karasuma Wada Clinic, Nakagyo-ku, Kyoto, 604-0845, Japan.
Hamaguchi R; Karasuma Wada Clinic, Nakagyo-ku, Kyoto, 604-0845, Japan.
Nobukawa T; Kotosugi Co., Ltd, Sagamihara, Japan.
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Źródło :
Scientific reports [Sci Rep] 2022 Apr 15; Vol. 12 (1), pp. 6282. Date of Electronic Publication: 2022 Apr 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
Taxus*/metabolism
Animals ; Apoptosis ; Cell Death ; Cell Line, Tumor ; Membrane Glycoproteins/metabolism ; Mice ; Plant Extracts/pharmacology ; TNF-Related Apoptosis-Inducing Ligand/pharmacology ; Wood/metabolism
Czasopismo naukowe
Tytuł :
Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol.
Autorzy :
Hellwig CT; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.; Stuttgart Research Center Systems Biology, University of Stuttgart, Stuttgart, Germany.
Delgado ME; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany.
Skoko J; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Dyck L; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Hanna C; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Wentges A; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Langlais C; MRC Toxicology Unit, Cambridge, UK.
Hagenlocher C; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Mack A; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Dinsdale D; MRC Toxicology Unit, Cambridge, UK.
Cain K; MRC Toxicology Unit, Cambridge, UK.
MacFarlane M; MRC Toxicology Unit, Cambridge, UK.
Rehm M; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland. .; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland. .; Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany. .; Stuttgart Research Center Systems Biology, University of Stuttgart, Stuttgart, Germany. .; Stuttgart Center for Simulation Science (SC SimTech), University of Stuttgart, Stuttgart, Germany. .
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Źródło :
Cell death and differentiation [Cell Death Differ] 2022 Jan; Vol. 29 (1), pp. 147-155. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Proteasome Endopeptidase Complex*/metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand*/genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
Apoptosis ; Caspase 8/metabolism ; Cytosol/metabolism ; TNF-Related Apoptosis-Inducing Ligand/metabolism ; TNF-Related Apoptosis-Inducing Ligand/pharmacology
Czasopismo naukowe
Tytuł :
Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis.
Autorzy :
Bella Á; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Arrizabalaga L; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Di Trani CA; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Cirella A; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Fernandez-Sendin M; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Gomar C; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Russo-Cabrera JS; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Rodríguez I; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
González-Gomariz J; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Alvarez M; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Teijeira Á; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Medina-Echeverz J; Immunology Research, Bavarian Nordic GmbH, Planegg, Germany.
Hinterberger M; Immunology Research, Bavarian Nordic GmbH, Planegg, Germany.
Hochrein H; Immunology Research, Bavarian Nordic GmbH, Planegg, Germany.
Melero I; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.; Department of Oncology, Clínica Universidad de Navarra, Pamplona, Spain.; Department of Immunology and Immunotherapy, Clínica Universidad de Navarra, Pamplona, Spain.
Berraondo P; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Aranda F; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
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Źródło :
Oncoimmunology [Oncoimmunology] 2022 Jul 13; Vol. 11 (1), pp. 2098657. Date of Electronic Publication: 2022 Jul 13 (Print Publication: 2022).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Peritoneal Neoplasms*/therapy
Vaccinia*
4-1BB Ligand/*metabolism
Animals ; CD40 Ligand/genetics ; Immunity ; Mice ; Vaccinia virus/genetics
Czasopismo naukowe
Tytuł :
CSC-3436 sensitizes triple negative breast cancer cells to TRAIL-induced apoptosis through ROS-mediated p38/CHOP/death receptor 5 signaling pathways.
Autorzy :
Huang CC; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.
Cheng YC; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.
Lin YC; Division of Neurosurgery, Buddhist Tzu Chi General Hospital, Taichung Branch, Taichung, Taiwan.; School of Medicine, Tzu Chi University, Hualien, Taiwan.; Department of Medical Imaging and Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Chou CH; Ph.D. Program for Biotechnology Industry, College of Life Sciences, China Medical University, Taichung, Taiwan.
Ho CT; Department of Food Science, Rutgers University, New Brunswick, New Jersey, USA.
Wang HK; Department of Neurosurgery, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan.; School of Medicine, I-Shou University, Kaohsiung, Taiwan.
Way TD; Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.; Ph.D. Program for Biotechnology Industry, College of Life Sciences, China Medical University, Taichung, Taiwan.; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
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Źródło :
Environmental toxicology [Environ Toxicol] 2021 Dec; Vol. 36 (12), pp. 2578-2588. Date of Electronic Publication: 2021 Oct 02.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*/genetics
Triple Negative Breast Neoplasms*
Apoptosis ; Cell Line, Tumor ; Humans ; Ligands ; Naphthyridines ; Reactive Oxygen Species ; TNF-Related Apoptosis-Inducing Ligand ; Transcription Factor CHOP/genetics
Czasopismo naukowe
Tytuł :
Modulating Oncolytic Adenovirus Immunotherapy by Driving Two Axes of the Immune System by Expressing 4-1BBL and CD40L.
Autorzy :
Lu SC; Virology and Gene Therapy Graduate Program, Mayo Clinic, Rochester, Minnesota, USA.
Hansen MJ; Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA.; Department of Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Hemsath JR; Department of Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Parrett BJ; Virology and Gene Therapy Graduate Program, Mayo Clinic, Rochester, Minnesota, USA.
Zell BN; Virology and Gene Therapy Graduate Program, Mayo Clinic, Rochester, Minnesota, USA.
Barry MA; Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
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Źródło :
Human gene therapy [Hum Gene Ther] 2022 Mar; Vol. 33 (5-6), pp. 250-261. Date of Electronic Publication: 2022 Jan 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Melanoma, Experimental*/genetics
Melanoma, Experimental*/therapy
Oncolytic Viruses*/genetics
4-1BB Ligand/*metabolism
Adenoviridae/metabolism ; Animals ; CD40 Ligand/genetics ; CD40 Ligand/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Cell Line, Tumor ; Immunotherapy ; Mice
Czasopismo naukowe
Tytuł :
Cytoprotective effect of genistein against dexamethasone-induced pancreatic β-cell apoptosis.
Autorzy :
Suksri K; Division of Endocrinology, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.
Semprasert N; Division of Endocrinology, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.
Limjindaporn T; Department of Anatomy, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Yenchitsomanus PT; Division of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Kooptiwoot S; Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Kooptiwut S; Division of Endocrinology, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand. S_.
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Źródło :
Scientific reports [Sci Rep] 2022 Jul 28; Vol. 12 (1), pp. 12950. Date of Electronic Publication: 2022 Jul 28.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
TNF-Related Apoptosis-Inducing Ligand*/pharmacology
Animals ; Apoptosis ; Apoptosis Regulatory Proteins/metabolism ; Caspase 3/metabolism ; Caspase 8/metabolism ; Cell Line, Tumor ; Dexamethasone/adverse effects ; Genistein/pharmacology ; Mice ; NF-kappa B/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Rats ; Superoxides/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Biosynthetic cell membrane vesicles to enhance TRAIL-mediated apoptosis driven by photo-triggered oxidative stress.
Autorzy :
Li F; School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, P.R. China.; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China. .
Wang X; School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, P.R. China.; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China. .
Wu M; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China. .; Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China.
Guan J; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China. .; College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, P. R. China.
Liang Y; School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, P.R. China.; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China. .
Liu X; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China. .; Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China.
Lin X; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China. .; Mengchao Med-X Center, Fuzhou University, Fuzhou 350116, P. R. China.
Liu J; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China. .; Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou 350014, P. R. China.
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Źródło :
Biomaterials science [Biomater Sci] 2022 Jun 28; Vol. 10 (13), pp. 3547-3558. Date of Electronic Publication: 2022 Jun 28.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, TNF-Related Apoptosis-Inducing Ligand*
TNF-Related Apoptosis-Inducing Ligand*/metabolism
TNF-Related Apoptosis-Inducing Ligand*/pharmacology
Apoptosis ; Carrier Proteins/metabolism ; Cell Membrane/metabolism ; Cytochromes c/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Recent Insight into Lipid Binding and Lipid Modulation of Pentameric Ligand-Gated Ion Channels.
Autorzy :
Ananchenko A; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.
Hussein TOK; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.
Mody D; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.
Thompson MJ; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.
Baenziger JE; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada.
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Źródło :
Biomolecules [Biomolecules] 2022 Jun 10; Vol. 12 (6). Date of Electronic Publication: 2022 Jun 10.
Typ publikacji :
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms :
Ligand-Gated Ion Channels*/chemistry
Ligand-Gated Ion Channels*/metabolism
Binding Sites ; Lipids
Czasopismo naukowe
Tytuł :
TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex.
Autorzy :
Airiau K; Institut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.
Vacher P; Institut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.
Micheau O; Lipides, Nutrition Cancer, INSERM, UMR1231, 21079 Dijon, France.; UFR Science de Santé, Université de Bourgogne, Franche-Comté, 21079 Dijon, France.
Prouzet-Mauleon V; Institut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.
Kroemer G; Centre de Recherche des Cordeliers, INSERM UMRS 1138, Sorbonne Université, Université de Paris, Equipe 11 Labellisée par la Ligue Contre le Cancer, 75006 Paris, France.; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France.; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France.
Moosavi MA; Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran P.O. Box 14965/161, Iran.
Djavaheri-Mergny M; Centre de Recherche des Cordeliers, INSERM UMRS 1138, Sorbonne Université, Université de Paris, Equipe 11 Labellisée par la Ligue Contre le Cancer, 75006 Paris, France.; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France.
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Źródło :
Cells [Cells] 2021 Dec 25; Vol. 11 (1). Date of Electronic Publication: 2021 Dec 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*/drug effects
Autophagy-Related Proteins/*metabolism
Calcium/*metabolism
Calcium Channels/*metabolism
Death Domain Receptor Signaling Adaptor Proteins/*metabolism
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Cytoprotection/drug effects ; Drug Resistance, Neoplasm/drug effects ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Homeostasis/drug effects ; Humans ; Jurkat Cells ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism ; Sequence Analysis, RNA ; Tretinoin/pharmacology
Czasopismo naukowe
Tytuł :
The Novel, Orally Bioavailable CDK9 Inhibitor Atuveciclib Sensitises Pancreatic Cancer Cells to TRAIL-induced Cell Death.
Autorzy :
Ruff JP; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
Kretz AL; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
Kornmann M; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
Henne-Bruns D; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
Lemke J; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany .
Traub B; Department of General and Visceral Surgery, University of Ulm, Ulm, Germany.
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Źródło :
Anticancer research [Anticancer Res] 2021 Dec; Vol. 41 (12), pp. 5973-5985.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Cyclin-Dependent Kinase 9/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Sulfonamides/*pharmacology
TNF-Related Apoptosis-Inducing Ligand/*pharmacology
Triazines/*pharmacology
Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Synergism ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism
Czasopismo naukowe
Tytuł :
Overcoming therapeutic efficiency limitations against TRAIL-resistant tumors using re-sensitizing agent-loaded trimeric TRAIL-presenting nanocages.
Autorzy :
Je H; Department of Chemical Engineering, School of Applied Chemical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea.
Nam GH; Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.
Kim GB; Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
Kim W; Department of Chemical Engineering, School of Applied Chemical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea.
Kim SR; School of Food Science and Biotechnology, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea.
Kim IS; Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea. Electronic address: .
Lee EJ; Department of Chemical Engineering, School of Applied Chemical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea. Electronic address: .
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Źródło :
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2021 Mar 10; Vol. 331, pp. 7-18. Date of Electronic Publication: 2021 Jan 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Neoplasms*/drug therapy
TNF-Related Apoptosis-Inducing Ligand*
Apoptosis ; Cell Line, Tumor ; Doxorubicin ; Humans ; Receptors, TNF-Related Apoptosis-Inducing Ligand
Czasopismo naukowe
Tytuł :
In vitro 2D and 3D cancer models to evaluate compounds that modulate macrophage polarization.
Autorzy :
Helleberg Madsen N; Bioneer A/S, Kogle Allé 2, 2970 Hørsholm, Denmark. Electronic address: .
Schnack Nielsen B; Bioneer A/S, Kogle Allé 2, 2970 Hørsholm, Denmark.
Larsen J; Bioneer A/S, Kogle Allé 2, 2970 Hørsholm, Denmark.
Gad M; Bioneer A/S, Kogle Allé 2, 2970 Hørsholm, Denmark.
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Źródło :
Cellular immunology [Cell Immunol] 2022 Aug; Vol. 378, pp. 104574. Date of Electronic Publication: 2022 Jun 23.
Typ publikacji :
Journal Article
MeSH Terms :
CD40 Ligand*/metabolism
Neoplasms*/pathology
Macrophage Activation ; Macrophages/metabolism ; Monocytes/metabolism ; Poly I/metabolism ; Poly I/pharmacology
Czasopismo naukowe
Tytuł :
TRAIL protects the immature lung from hyperoxic injury.
Autorzy :
Shahzad T; Department of General Pediatrics and Neonatology, Justus-Liebig-University and Universities of Giessen and Marburg Lung Center (UGMLC), Feulgenstrasse 12, Giessen, Germany.; German Lung Research Center (DZL), Giessen, Germany.
Chao CM; Department of General Pediatrics and Neonatology, Justus-Liebig-University and Universities of Giessen and Marburg Lung Center (UGMLC), Feulgenstrasse 12, Giessen, Germany.; German Lung Research Center (DZL), Giessen, Germany.; Department of Internal Medicine II, Universities of Giessen and Marburg Lung Center (UGMLC), Cardio-Pulmonary Institute (CPI), Aulweg 130, Giessen, Germany.; University Medical Centre Rostock, Department of Pediatrics, University of Rostock, Ernst-Heydemann-Strasse 8, Rostock, Germany.
Hadzic S; German Lung Research Center (DZL), Giessen, Germany.; Department of Internal Medicine II, Universities of Giessen and Marburg Lung Center (UGMLC), Cardio-Pulmonary Institute (CPI), Aulweg 130, Giessen, Germany.
Behnke J; Department of General Pediatrics and Neonatology, Justus-Liebig-University and Universities of Giessen and Marburg Lung Center (UGMLC), Feulgenstrasse 12, Giessen, Germany.; German Lung Research Center (DZL), Giessen, Germany.
Biebach L; Division of Neonatology, University Children's Hospital, Perinatal Center, Ludwig-Maximilians-University, Campus Großhadern, Marchioninistrasse 15, Munich, Germany.
Böttcher-Friebertshäuser E; Institute of Virology, Philipps University Marburg, Hans-Meerwein-Strasse 2, 35043, Marburg, Germany.
Wilhelm J; German Lung Research Center (DZL), Giessen, Germany.; Department of Internal Medicine II, Universities of Giessen and Marburg Lung Center (UGMLC), Cardio-Pulmonary Institute (CPI), Aulweg 130, Giessen, Germany.
Hilgendorff A; German Lung Research Center (DZL), Giessen, Germany.; Division of Neonatology, University Children's Hospital, Perinatal Center, Ludwig-Maximilians-University, Campus Großhadern, Marchioninistrasse 15, Munich, Germany.; Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum München, Munich, Germany.
Zimmer KP; Department of General Pediatrics and Neonatology, Justus-Liebig-University and Universities of Giessen and Marburg Lung Center (UGMLC), Feulgenstrasse 12, Giessen, Germany.
Morty RE; German Lung Research Center (DZL), Giessen, Germany.; Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Bellusci S; German Lung Research Center (DZL), Giessen, Germany.; Department of Internal Medicine II, Universities of Giessen and Marburg Lung Center (UGMLC), Cardio-Pulmonary Institute (CPI), Aulweg 130, Giessen, Germany.
Ehrhardt H; Department of General Pediatrics and Neonatology, Justus-Liebig-University and Universities of Giessen and Marburg Lung Center (UGMLC), Feulgenstrasse 12, Giessen, Germany. .; German Lung Research Center (DZL), Giessen, Germany. .
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Źródło :
Cell death & disease [Cell Death Dis] 2022 Jul 15; Vol. 13 (7), pp. 614. Date of Electronic Publication: 2022 Jul 15.
Typ publikacji :
Journal Article
MeSH Terms :
Bronchopulmonary Dysplasia*/metabolism
Hyperoxia*/complications
Hyperoxia*/genetics
Hyperoxia*/metabolism
TNF-Related Apoptosis-Inducing Ligand*/chemistry
TNF-Related Apoptosis-Inducing Ligand*/metabolism
Animals ; Animals, Newborn ; Endothelial Cells/metabolism ; Humans ; Infant, Newborn ; Infant, Premature ; Ligands ; Lung/metabolism ; Mice ; NF-kappa B/metabolism ; Oxygen/metabolism
Czasopismo naukowe
Tytuł :
Protein and functional isoform levels and genetic variants of the BAFF and APRIL pathway components in systemic lupus erythematosus.
Autorzy :
Ortiz-Aljaro P; Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), 41013, Seville, Spain.
Montes-Cano MA; Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), 41013, Seville, Spain.
García-Lozano JR; Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), 41013, Seville, Spain.
Aquino V; Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, 41013, Seville, Spain.
Carmona R; Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, 41013, Seville, Spain.; Bioinformatics in Rare Diseases (BiER), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), FPS, Hospital Virgen del Rocío, Seville, Spain.
Perez-Florido J; Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, 41013, Seville, Spain.; Bioinformatics in Rare Diseases (BiER), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), FPS, Hospital Virgen del Rocío, Seville, Spain.; Computational Systems Medicine, Institute of Biomedicine of Seville (IBIS), Hospital Virgen del Rocio, Seville, Spain.
García-Hernández FJ; Department of Internal Medicine, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), 41013, Seville, Spain.
Dopazo J; Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, 41013, Seville, Spain.; Bioinformatics in Rare Diseases (BiER), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), FPS, Hospital Virgen del Rocío, Seville, Spain.; Computational Systems Medicine, Institute of Biomedicine of Seville (IBIS), Hospital Virgen del Rocio, Seville, Spain.; Functional Genomics Node, FPS/ELIXIR-es, Hospital Virgen del Rocío, Seville, Spain.
González-Escribano MF; Department of Immunology, Hospital Universitario Virgen del Rocío (IBiS, CSIC, US), 41013, Seville, Spain. .
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Źródło :
Scientific reports [Sci Rep] 2022 Jul 02; Vol. 12 (1), pp. 11219. Date of Electronic Publication: 2022 Jul 02.
Typ publikacji :
Journal Article
MeSH Terms :
B-Cell Activating Factor*/genetics
B-Cell Activating Factor*/metabolism
Lupus Erythematosus, Systemic*/genetics
Lupus Erythematosus, Systemic*/metabolism
Lupus Nephritis*/genetics
Lupus Nephritis*/metabolism
Tumor Necrosis Factor Ligand Superfamily Member 13*/genetics
Tumor Necrosis Factor Ligand Superfamily Member 13*/metabolism
Adolescent ; Adult ; B-Cell Maturation Antigen/genetics ; B-Cell Maturation Antigen/metabolism ; Case-Control Studies ; Female ; Humans ; Middle Aged ; Protein Isoforms ; Young Adult
Czasopismo naukowe
Tytuł :
Distinct functional roles for the M4 α-helix from each homologous subunit in the heteropentameric ligand-gated ion channel nAChR.
Autorzy :
Thompson MJ; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
Domville JA; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
Edrington CH; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
Venes A; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
Giguère PM; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
Baenziger JE; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2022 Jul; Vol. 298 (7), pp. 102104. Date of Electronic Publication: 2022 Jun 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ligand-Gated Ion Channels*/chemistry
Receptors, Nicotinic*/metabolism
Adult ; Alanine ; Humans ; Membrane Lipids/chemistry ; Protein Conformation, alpha-Helical
Czasopismo naukowe
Tytuł :
Identification of Novel Genes for Cell Fusion during Osteoclast Formation.
Autorzy :
Cho E; Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.
Cheon S; School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Korea.; Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Korea.
Ding M; Biomedical Sciences Graduate Program, School of Medical, Chonnam National University, Gwangju 61186, Korea.
Lim K; Center for Genome Engineering, Institute for Basic Science, Daejeon 34126, Korea.
Park SW; Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.
Park C; School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Korea.
Lee TH; Department of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Jun 08; Vol. 23 (12). Date of Electronic Publication: 2022 Jun 08.
Typ publikacji :
Journal Article
MeSH Terms :
Osteoclasts*/metabolism
RANK Ligand*/genetics
RANK Ligand*/metabolism
Cell Differentiation/genetics ; Cell Fusion ; Giant Cells/metabolism ; Hematopoietic Stem Cells/metabolism ; Macrophages/metabolism
Czasopismo naukowe
Tytuł :
MicroRNA-148a Inhibits Hepatocellular Carcinoma Cell Growth via Epithelial-to-Mesenchymal Transition and PI3K/AKT Signaling Pathways by Targeting Death Receptor-5.
Autorzy :
Zhang N; Department of General Surgery, Hongqi Hospital affiliated to Mudanjiang Medical University, No.5, Tongxiang Road, Aimin District, Heilongjiang Province, 157000, Mudanjiang City, China.
Zhou J; Department of General Surgery, Hongqi Hospital affiliated to Mudanjiang Medical University, No.5, Tongxiang Road, Aimin District, Heilongjiang Province, 157000, Mudanjiang City, China.
Zhou Y; Department of Stomatology, Hongqi Hospital affiliated to Mudanjiang Medical University, 157000, Mudanjiang City, China.
Guan F; Department of General Surgery, Hongqi Hospital affiliated to Mudanjiang Medical University, No.5, Tongxiang Road, Aimin District, Heilongjiang Province, 157000, Mudanjiang City, China. .
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Źródło :
Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2022 Jun; Vol. 194 (6), pp. 2731-2746. Date of Electronic Publication: 2022 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*/pathology
Epithelial-Mesenchymal Transition*/genetics
Liver Neoplasms*/pathology
MicroRNAs*/genetics
MicroRNAs*/metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand*/genetics
Receptors, TNF-Related Apoptosis-Inducing Ligand*/metabolism
Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/genetics
Czasopismo naukowe

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