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Tytuł :
Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population.
Autorzy :
Parker CC; Department of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
Philip VM; Center for Computational Sciences, The Jackson Laboratory, Bar Harbor, Maine, USA.
Gatti DM; Center for Computational Sciences, The Jackson Laboratory, Bar Harbor, Maine, USA.
Kasparek S; Department of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
Kreuzman AM; Department of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
Kuffler L; Center for Mammalian Genetics, The Jackson Laboratory, Bar Harbor, Maine, USA.
Mansky B; Department of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
Masneuf S; Laboratory of Behavioral and Genomic Neuroscience, NIAAA, NIH, Rockville, MD, USA.
Sharif K; Department of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
Sluys E; Laboratory of Behavioral and Genomic Neuroscience, NIAAA, NIH, Rockville, MD, USA.
Taterra D; Department of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
Taylor WM; Department of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
Thomas M; Department of Psychology and Program in Neuroscience, Middlebury College, Middlebury, Vermont, USA.
Polesskaya O; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA.
Palmer AA; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA.
Holmes A; Laboratory of Behavioral and Genomic Neuroscience, NIAAA, NIH, Rockville, MD, USA.
Chesler EJ; Center for Mammalian Genetics, The Jackson Laboratory, Bar Harbor, Maine, USA.
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Źródło :
Alcoholism, clinical and experimental research [Alcohol Clin Exp Res] 2022 Jun; Vol. 46 (6), pp. 941-960. Date of Electronic Publication: 2022 Apr 17.
Typ publikacji :
Journal Article
MeSH Terms :
Alcoholism*/genetics
Collaborative Cross Mice*/genetics
Animals ; Chromosome Mapping/methods ; Ethanol/pharmacology ; Genome-Wide Association Study ; Male ; Mice ; Quantitative Trait Loci
Czasopismo naukowe
Tytuł :
A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors.
Autorzy :
Hackett JB; Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
Glassbrook JE; Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.; Department of Biochemistry Microbiology Immunology, Wayne State University, Detroit, MI, USA.
Muñiz MC; Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
Bross M; Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
Fielder A; Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
Dyson G; Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
Movahhedin N; Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
McCasland J; Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
McCarthy-Leo C; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA.
Gibson HM; Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
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Źródło :
Oncoimmunology [Oncoimmunology] 2022 Apr 20; Vol. 11 (1), pp. 2064958. Date of Electronic Publication: 2022 Apr 20 (Print Publication: 2022).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Collaborative Cross Mice*
Immune Checkpoint Inhibitors*/pharmacology
Immune Checkpoint Inhibitors*/therapeutic use
Animals ; Genotype ; Mice ; Mice, Inbred C57BL ; Prolactin
Czasopismo naukowe
Tytuł :
Progress towards completing the mutant mouse null resource.
Autorzy :
Peterson KA; The Jackson Laboratory, Bar Harbor, ME, USA. .
Murray SA; The Jackson Laboratory, Bar Harbor, ME, USA. .
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Źródło :
Mammalian genome : official journal of the International Mammalian Genome Society [Mamm Genome] 2022 Mar; Vol. 33 (1), pp. 123-134. Date of Electronic Publication: 2021 Oct 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Genome*
Mice*/genetics
Animals ; Gene Knockout Techniques ; Mice, Knockout ; Mutagenesis ; Phenotype
Czasopismo naukowe
Tytuł :
Noncognitive species-typical and home-cage behavioral alterations in conditional presenilin 1/presenilin 2 double knockout mice.
Autorzy :
Si Y; Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, Shanghai 200062, China.
Guo C; Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, Shanghai 200062, China; Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegne, Netherlands.
Xiao F; Department of Prosthodontics, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China.
Mei B; Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, Shanghai 200062, China. Electronic address: .
Meng B; Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, Shanghai 200062, China. Electronic address: .
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Źródło :
Behavioural brain research [Behav Brain Res] 2022 Feb 10; Vol. 418, pp. 113652. Date of Electronic Publication: 2021 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mice, Knockout*
Behavior, Animal/*physiology
Feeding Behavior/*physiology
Presenilin-1/*genetics
Presenilin-2/*genetics
Animals ; Female ; Male ; Mice
Czasopismo naukowe
Tytuł :
Age-related cognitive decline in spatial learning and memory of C57BL/6J mice.
Autorzy :
Hendrickx JO; Laboratory of Physiopharmacology, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
De Moudt S; Laboratory of Physiopharmacology, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
Calus E; Laboratory of Neurochemistry and Behaviour, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
De Deyn PP; Laboratory of Neurochemistry and Behaviour, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Van Dam D; Laboratory of Neurochemistry and Behaviour, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
De Meyer GRY; Laboratory of Physiopharmacology, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium. Electronic address: .
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Źródło :
Behavioural brain research [Behav Brain Res] 2022 Feb 10; Vol. 418, pp. 113649. Date of Electronic Publication: 2021 Oct 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mice, Inbred C57BL*
Aging/*physiology
Cognitive Dysfunction/*physiopathology
Memory/*physiology
Spatial Learning/*physiology
Animals ; Disease Models, Animal ; Hippocampus ; Male ; Mice ; Morris Water Maze Test ; Open Field Test
Czasopismo naukowe
Tytuł :
Humanized Mouse Models of Systemic Lupus Erythematosus: Opportunities and Challenges.
Autorzy :
Chen J; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Liao S; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Zhou H; Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang, China.
Yang L; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Guo F; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Chen S; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Li A; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Pan Q; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Yang C; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Liu HF; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Pan Q; Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2022 Jan 18; Vol. 12, pp. 816956. Date of Electronic Publication: 2022 Jan 18 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Disease Models, Animal*
Mice, Transgenic*
Lupus Erythematosus, Systemic/*etiology
Lupus Erythematosus, Systemic/*metabolism
Animals ; Autoantibodies/immunology ; Autoantigens/immunology ; Autoimmune Diseases ; Autoimmunity ; Biomarkers ; Disease Management ; Disease Susceptibility/immunology ; Humans ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/therapy ; Mice
Czasopismo naukowe
Tytuł :
TRAPing Ghrelin-Activated Circuits: A Novel Tool to Identify, Target and Control Hormone-Responsive Populations in TRAP2 Mice.
Autorzy :
Stoltenborg I; Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30 Gothenburg, Sweden.
Peris-Sampedro F; Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30 Gothenburg, Sweden.
Schéle E; Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30 Gothenburg, Sweden.
Le May MV; Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30 Gothenburg, Sweden.
Adan RAH; Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30 Gothenburg, Sweden.; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht and Utrecht University, 3584 CJ Utrecht, The Netherlands.
Dickson SL; Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30 Gothenburg, Sweden.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Jan 05; Vol. 23 (1). Date of Electronic Publication: 2022 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*/drug effects
Mice, Transgenic*
Ghrelin/*metabolism
Receptors, Ghrelin/*genetics
Animals ; Eating ; Female ; Food Preferences ; Gene Order ; Gene Targeting/methods ; Genetic Vectors/genetics ; Ghrelin/pharmacology ; Homologous Recombination ; Male ; Mice ; Neurons/metabolism ; Phenotype ; Receptors, Ghrelin/metabolism ; Sex Factors ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
High Fat Diet Mediates Amyloid-β Cleaving Enzyme 1 Phosphorylation and SUMOylation, Enhancing Cognitive Impairment in APP/PS1 Mice.
Autorzy :
Bao J; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, China.
Liang Z; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.
Gong X; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.
Yu J; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, China.
Xiao Y; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, China.
Liu W; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, China.
Wang X; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang JZ; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Shu X; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, China.
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Źródło :
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2022; Vol. 85 (2), pp. 863-876.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mice, Transgenic*
Alzheimer Disease/*pathology
Amyloid Precursor Protein Secretases/*metabolism
Amyloid beta-Peptides/*metabolism
Diet, High-Fat/*adverse effects
Animals ; Brain/pathology ; Cognitive Dysfunction/pathology ; Disease Models, Animal ; Male ; Maze Learning ; Memory Disorders/pathology ; Mice ; Phosphorylation ; Plaque, Amyloid/pathology ; Sumoylation
Czasopismo naukowe
Tytuł :
Sex-specific behavioral and structural alterations caused by early-life stress in C57BL/6 and BTBR mice.
Autorzy :
Reshetnikov VV; Institute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), Prospekt Lavrentyeva 10, Novosibirsk, 630090, Russia. Electronic address: .
Ayriyants KA; Institute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), Prospekt Lavrentyeva 10, Novosibirsk, 630090, Russia.
Ryabushkina YA; Institute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), Prospekt Lavrentyeva 10, Novosibirsk, 630090, Russia.
Sozonov NG; Institute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), Prospekt Lavrentyeva 10, Novosibirsk, 630090, Russia; Novosibirsk State University, Pirogov Avenue 2, Novosibirsk, 630090, Russia.
Bondar NP; Institute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), Prospekt Lavrentyeva 10, Novosibirsk, 630090, Russia.
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Źródło :
Behavioural brain research [Behav Brain Res] 2021 Sep 24; Vol. 414, pp. 113489. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mice, Inbred Strains*
Behavior, Animal/*physiology
Brain/*pathology
Stress, Psychological/*pathology
Stress, Psychological/*physiopathology
Age Factors ; Animals ; Disease Models, Animal ; Female ; Male ; Maternal Deprivation ; Mice ; Mice, Inbred C57BL ; Sex Characteristics
Czasopismo naukowe
Tytuł :
Rapid generation of conditional knockout mice using the CRISPR-Cas9 system and electroporation for neuroscience research.
Autorzy :
Nishizono H; Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan. .; Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL, 33458, USA. .
Hayano Y; Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL, 33458, USA.
Nakahata Y; Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL, 33458, USA.
Ishigaki Y; Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan.
Yasuda R; Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL, 33458, USA. .
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Źródło :
Molecular brain [Mol Brain] 2021 Sep 23; Vol. 14 (1), pp. 148. Date of Electronic Publication: 2021 Sep 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
CRISPR-Cas Systems*
Mice, Knockout*
Electroporation/*methods
Gene Editing/*methods
Gene Targeting/*methods
Neurosciences/*methods
Animals ; Base Sequence ; Calcium-Calmodulin-Dependent Protein Kinase Type 1/genetics ; Embryo Transfer ; Exons/genetics ; Gene Editing/economics ; Gene Targeting/economics ; Integrases ; Mice ; Mice, Inbred C57BL ; Neurosciences/economics ; Transgenes
Czasopismo naukowe
Tytuł :
A Novel Model for Papillomavirus-Mediated Anal Disease and Cancer Using the Mouse Papillomavirus.
Autorzy :
Blaine-Sauer S; McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Healthgrid.471391.9, Madison, Wisconsin, USA.
Shin MK; McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Healthgrid.471391.9, Madison, Wisconsin, USA.
Matkowskyj KA; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Healthgrid.471391.9, Madison, Wisconsin, USA.; University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA.; William S. Middleton VA Medical Center, Madison, Wisconsin, USA.
Ward-Shaw E; McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Healthgrid.471391.9, Madison, Wisconsin, USA.
Lambert PF; McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Healthgrid.471391.9, Madison, Wisconsin, USA.; University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA.
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Źródło :
MBio [mBio] 2021 Aug 31; Vol. 12 (4), pp. e0161121. Date of Electronic Publication: 2021 Jul 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Mice*
Anal Canal/*pathology
Anal Canal/*virology
Anus Neoplasms/*virology
Papillomaviridae/*pathogenicity
Papillomavirus Infections/*complications
Animals ; Anthracenes/administration & dosage ; Anus Neoplasms/chemically induced ; Female ; Male ; Mice, Inbred NOD ; Mice, SCID ; Papillomavirus Infections/pathology ; Piperidines/administration & dosage ; Squamous Intraepithelial Lesions/pathology ; Squamous Intraepithelial Lesions/virology ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
A systems approach using Diversity Outbred mice distinguishes the cardiovascular effects and genetics of circulating GDF11 from those of its homolog, myostatin.
Autorzy :
Starcher AE; Department of Nutritional Sciences, University of Georgia, Athens, GA 30602, USA.
Peissig K; Department of Nutritional Sciences, University of Georgia, Athens, GA 30602, USA.
Stanton JB; Department of Pathology, University of Georgia College of Veterinary Medicine, Athens, GA 30602, USA.
Churchill GA; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Cai D; Department of Physiology, University of Georgia College of Veterinary Medicine, Athens, GA 30602, USA.
Maxwell JT; Department of Pediatrics, Emory School of Medicine, Atlanta, GA 30322, USA.
Grider A; Department of Nutritional Sciences, University of Georgia, Athens, GA 30602, USA.
Love K; K. R. Love Quantitative Consulting and Collaboration, Athens, GA 30605, USA.
Chen SY; Department of Physiology, University of Georgia College of Veterinary Medicine, Athens, GA 30602, USA.
Coleman AE; Department of Small Animal Medicine & Surgery, University of Georgia College of Veterinary Medicine, Athens, GA 30602, USA.
Strauss E; Department of Nutritional Sciences, University of Georgia, Athens, GA 30602, USA.
Pazdro R; Department of Nutritional Sciences, University of Georgia, Athens, GA 30602, USA.
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Źródło :
G3 (Bethesda, Md.) [G3 (Bethesda)] 2021 Oct 19; Vol. 11 (11).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Collaborative Cross Mice*
Myostatin*/genetics
Animals ; Bone Morphogenetic Proteins/genetics ; Growth Differentiation Factors/genetics ; Mice ; Systems Analysis ; Transforming Growth Factor beta
Czasopismo naukowe
Tytuł :
Identification of sample mix-ups and mixtures in microbiome data in Diversity Outbred mice.
Autorzy :
Lobo AK; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53706, USA.
Traeger LL; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Keller MP; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Attie AD; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Rey FE; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Broman KW; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53706, USA.
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Źródło :
G3 (Bethesda, Md.) [G3 (Bethesda)] 2021 Oct 19; Vol. 11 (11).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Collaborative Cross Mice*
Microbiota*/genetics
Animals ; Genotype ; Mice ; Quantitative Trait Loci
Czasopismo naukowe
Tytuł :
A Tendon-Specific Double Reporter Transgenic Mouse Enables Tracking Cell Lineage and Functions Alteration In Vitro and In Vivo.
Autorzy :
Chen R; Department of Neuroanatomy, Group for Regeneration and Reprogramming, Institute for Anatomy and Cell Biology, Medical Faculty, Heidelberg University, 69120 Heidelberg, Germany.
Zhou X; Department of Neuroanatomy, Group for Regeneration and Reprogramming, Institute for Anatomy and Cell Biology, Medical Faculty, Heidelberg University, 69120 Heidelberg, Germany.
Skutella T; Department of Neuroanatomy, Group for Regeneration and Reprogramming, Institute for Anatomy and Cell Biology, Medical Faculty, Heidelberg University, 69120 Heidelberg, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 17; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Mice, Transgenic*
Promoter Regions, Genetic*
Basic Helix-Loop-Helix Transcription Factors/*genetics
Collagen Type I, alpha 1 Chain/*genetics
Tendons/*metabolism
Animals ; Cell Tracking ; Mesenchymal Stem Cells ; Mice ; Tendons/growth & development ; Tendons/physiology
Czasopismo naukowe
Tytuł :
Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease.
Autorzy :
Blumenstock S; Department of Molecules - Signaling - Development, Max Planck Institute of Neurobiology, Martinsried, Germany.; Molecular Neurodegeneration Group, Max Planck Institute of Neurobiology, Martinsried, Germany.
Schulz-Trieglaff EK; Department of Molecules - Signaling - Development, Max Planck Institute of Neurobiology, Martinsried, Germany.
Voelkl K; Department of Molecules - Signaling - Development, Max Planck Institute of Neurobiology, Martinsried, Germany.; Molecular Neurodegeneration Group, Max Planck Institute of Neurobiology, Martinsried, Germany.
Bolender AL; Department of Molecules - Signaling - Development, Max Planck Institute of Neurobiology, Martinsried, Germany.; Molecular Neurodegeneration Group, Max Planck Institute of Neurobiology, Martinsried, Germany.
Lapios P; Department of Molecules - Signaling - Development, Max Planck Institute of Neurobiology, Martinsried, Germany.; Molecular Neurodegeneration Group, Max Planck Institute of Neurobiology, Martinsried, Germany.
Lindner J; Department of Molecules - Signaling - Development, Max Planck Institute of Neurobiology, Martinsried, Germany.
Hipp MS; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany.; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Hartl FU; Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Martinsried, Germany.
Klein R; Department of Molecules - Signaling - Development, Max Planck Institute of Neurobiology, Martinsried, Germany.
Dudanova I; Department of Molecules - Signaling - Development, Max Planck Institute of Neurobiology, Martinsried, Germany.; Molecular Neurodegeneration Group, Max Planck Institute of Neurobiology, Martinsried, Germany.
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Źródło :
The EMBO journal [EMBO J] 2021 Oct 01; Vol. 40 (19), pp. e107260. Date of Electronic Publication: 2021 Aug 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Susceptibility*
Genes, Reporter*
Mice, Transgenic*
Proteostasis*
Aging/*metabolism
Neurons/*metabolism
Aging/genetics ; Animals ; Cells, Cultured ; Disease Models, Animal ; Gene Expression ; Hippocampus/metabolism ; Hippocampus/pathology ; Huntington Disease/etiology ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Mice ; Neurodegenerative Diseases/etiology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/pathology ; Protein Aggregates ; Protein Aggregation, Pathological ; Protein Folding ; Proteostasis Deficiencies/etiology ; Proteostasis Deficiencies/metabolism ; Proteostasis Deficiencies/pathology ; Tauopathies/etiology ; Tauopathies/metabolism ; Tauopathies/pathology
Czasopismo naukowe
Tytuł :
Removal of minute virus of mice-mock virus particles by nanofiltration of culture growth medium supplemented with 10% human platelet lysate.
Autorzy :
Barro L; International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
Delila L; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
Nebie O; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
Wu YW; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.
Knutson F; Clinical Immunology and Transfusion Medicine IGP, Uppsala University, Uppsala, Sweden.
Watanabe N; Asahi Kasei Medical Co, Ltd, Tokyo, Japan.
Takahara M; Asahi Kasei Medical Co, Ltd, Tokyo, Japan.
Burnouf T; International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; International Program in Cell Therapy and Regeneration Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: .
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Źródło :
Cytotherapy [Cytotherapy] 2021 Oct; Vol. 23 (10), pp. 902-907. Date of Electronic Publication: 2021 Jul 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mesenchymal Stem Cells*
Minute Virus of Mice*
Animals ; Cell Culture Techniques ; Culture Media ; Humans ; Mice ; Virion
Czasopismo naukowe
Tytuł :
Quantitative trait mapping in Diversity Outbred mice identifies novel genomic regions associated with the hepatic glutathione redox system.
Autorzy :
Gould RL; Department of Nutritional Sciences, University of Georgia, 305 Sanford Drive, Athens, GA, 30602, USA.
Craig SW; Department of Nutritional Sciences, University of Georgia, 305 Sanford Drive, Athens, GA, 30602, USA.
McClatchy S; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
Churchill GA; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
Pazdro R; Department of Nutritional Sciences, University of Georgia, 305 Sanford Drive, Athens, GA, 30602, USA. Electronic address: .
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Źródło :
Redox biology [Redox Biol] 2021 Oct; Vol. 46, pp. 102093. Date of Electronic Publication: 2021 Aug 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Collaborative Cross Mice*
Glutathione*/metabolism
Animals ; Genomics ; Glutathione Disulfide/metabolism ; Mice ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Immune response to dermatomyositis-specific autoantigen, transcriptional intermediary factor 1γ can result in experimental myositis.
Autorzy :
Okiyama N; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan .
Ichimura Y; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Shobo M; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Tanaka R; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Kubota N; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Saito A; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Ishitsuka Y; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.; Department of Integrative Medicine for Allergic and Immunological Disease, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Watanabe R; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.; Department of Integrative Medicine for Allergic and Immunological Disease, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Fujisawa Y; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Nakamura Y; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Murakami A; Medical and Biological Laboratories Co Ltd, Nagoya, Aichi, Japan.
Kayama H; Institute for Advanced Co-Creation Studies, Osaka University, Suita, Osaka, Japan.
Takeda K; Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Fujimoto M; Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.; Department of Dermatology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
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Źródło :
Annals of the rheumatic diseases [Ann Rheum Dis] 2021 Sep; Vol. 80 (9), pp. 1201-1208. Date of Electronic Publication: 2021 Apr 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Mice*
CD4-Positive T-Lymphocytes/*immunology
CD8-Positive T-Lymphocytes/*immunology
Dermatomyositis/*immunology
Nervous System Autoimmune Disease, Experimental/*immunology
Transcription Factors/*immunology
Adoptive Transfer ; Animals ; CD4-Positive T-Lymphocytes/transplantation ; CD8-Positive T-Lymphocytes/transplantation ; Humans ; Immunization ; Immunoglobulin G/immunology ; Immunoglobulin mu-Chains/genetics ; Janus Kinase Inhibitors/pharmacology ; Mice, Knockout ; Perforin/genetics ; Piperidines/pharmacology ; Pyrimidines/pharmacology ; Receptor, Interferon alpha-beta/genetics ; T-Lymphocytes/immunology ; beta 2-Microglobulin/genetics
Czasopismo naukowe
Tytuł :
Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification.
Autorzy :
Izzo NJ; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, USA.
Yuede CM; Washington University, St. Louis, Missouri, USA.
LaBarbera KM; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, USA.
Limegrover CS; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, USA.
Rehak C; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, USA.
Yurko R; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, USA.
Waybright L; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, USA.
Look G; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, USA.
Rishton G; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, USA.
Safferstein H; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, USA.
Hamby ME; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, USA.
Williams C; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, USA.
Sadlek K; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, USA.
Edwards HM; Washington University, St. Louis, Missouri, USA.
Davis CS; CSD Biostatistics Inc., Oro Valley, Arizona, USA.
Grundman M; Global R&D Partners, San Diego, California, USA.; University of California San Diego, San Diego, California, USA.
Schneider LS; Keck School of Medicine of USC, Los Angeles, California, USA.
DeKosky ST; McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Chelsky D; Caprion Biosciences, Montreal, Quebec, Canada.
Pike I; Proteome Sciences, London, UK.
Henstridge C; University of Dundee School of Medicine, Dundee, UK.
Blennow K; University of Gothenburg, Mölndal, Sweden.; Sahlgrenska University Hospital, Mölndal, Sweden.
Zetterberg H; University of Gothenburg, Mölndal, Sweden.; Sahlgrenska University Hospital, Mölndal, Sweden.; UCL Institute of Neurology, London, UK.
LeVine H 3rd; Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
Spires-Jones TL; The University of Edinburgh, Edinburgh, UK.
Cirrito JR; Washington University, St. Louis, Missouri, USA.
Catalano SM; Cognition Therapeutics Inc., Pittsburgh, Pennsylvania, USA.
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Źródło :
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2021 Aug; Vol. 17 (8), pp. 1365-1382. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mice, Transgenic*
Alzheimer Disease/*metabolism
Amyloid beta-Peptides/*cerebrospinal fluid
Biomarkers/*cerebrospinal fluid
Cognition/*drug effects
Receptors, sigma/*antagonists & inhibitors
Aged ; Animals ; Brain/metabolism ; Double-Blind Method ; Enzyme-Linked Immunosorbent Assay ; Hippocampus/metabolism ; Humans ; Male ; Mice ; Neurons/metabolism ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
Amyloid Beta Pathology Exacerbates Weight Loss and Brain Cytokine Responses following Low-Dose Lipopolysaccharide in Aged Female Tg2576 Mice.
Autorzy :
Knopp RC; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
Baumann KK; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
Wilson ML; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
Banks WA; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
Erickson MA; Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Feb 21; Vol. 23 (4). Date of Electronic Publication: 2022 Feb 21.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Peptides/*metabolism
Cytokines/*metabolism
Hippocampus/*metabolism
Lipopolysaccharides/*metabolism
Mice, Transgenic/*metabolism
Weight Loss/*physiology
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Disease Models, Animal ; Female ; Gliosis/metabolism ; Gliosis/pathology ; Hippocampus/pathology ; Inflammation/metabolism ; Mice ; Microglia/metabolism ; Microglia/pathology ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology
Czasopismo naukowe

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