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Podgląd okładki
Tytuł :
Low signaling efficiency from receptor to effector in olfactory transduction: A quantified ligand-triggered GPCR pathway.
Autorzy :
Li RC; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Molday LL; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Lin CC; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.; Neuroscience Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Ren X; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Fleischmann A; Department of Neuroscience, Brown University, Providence, RI 02912.
Molday RS; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Yau KW; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Aug 09; Vol. 119 (32), pp. e2121225119. Date of Electronic Publication: 2022 Aug 01.
Typ publikacji :
Journal Article
MeSH Terms :
Ligands*
Odorants*
Receptors, G-Protein-Coupled*/metabolism
Receptors, Odorant*/metabolism
Signal Transduction*
Smell*
Animals ; Light Signal Transduction ; Mammals/metabolism ; Retinal Rod Photoreceptor Cells
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Visual pigment-deficient cones survive and mediate visual signaling despite the lack of outer segments.
Autorzy :
Xu H; Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, UT 84132.; Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030.
Jin N; Ruiz Department of Ophthalmology and Visual Science, The University of Texas Health Science Center at Houston, Houston, TX 77030.
Chuang JZ; Department of Ophthalmology, Weill Cornell Medicine, New York, NY 10065.
Zhang Z; Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030.
Zhong X; Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030.
Zhang Z; Ruiz Department of Ophthalmology and Visual Science, The University of Texas Health Science Center at Houston, Houston, TX 77030.
Sung CH; Department of Ophthalmology, Weill Cornell Medicine, New York, NY 10065; .; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY 10065.
Ribelayga CP; Ruiz Department of Ophthalmology and Visual Science, The University of Texas Health Science Center at Houston, Houston, TX 77030; .
Fu Y; Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, UT 84132; .; Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Mar 01; Vol. 119 (9).
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Retinal Cone Photoreceptor Cells/*metabolism
Retinal Pigments/*metabolism
Animals ; Cone Opsins/genetics ; Electroretinography ; Light Signal Transduction ; Loss of Function Mutation ; Mice
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Mutated JAK2 signal transduction in human induced pluripotent stem cell (iPSC)-derived megakaryocytes.
Autorzy :
Pawinwongchai J; Faculty of Medical Technology, Rangsit University, Pathum Thani, Thailand.
Jangprasert P; Research Unit in Translational Hematology, Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Nilsri N; Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.
Israsena N; Stem Cell and Cell Therapy Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Rojnuckarin P; Research Unit in Translational Hematology, Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
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Źródło :
Platelets [Platelets] 2022 Jul 04; Vol. 33 (5), pp. 700-708. Date of Electronic Publication: 2021 Nov 09.
Typ publikacji :
Journal Article
MeSH Terms :
Induced Pluripotent Stem Cells*
Janus Kinase 2*/genetics
Janus Kinase 2*/metabolism
Signal Transduction*
Thrombocythemia, Essential*/genetics
Arsenic Trioxide/pharmacology ; Doxycycline ; Humans ; Interferon-alpha/pharmacology ; Megakaryocytes/metabolism ; Mutation ; Proto-Oncogene Proteins c-akt/metabolism ; STAT5 Transcription Factor/genetics ; STAT5 Transcription Factor/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
EGR1 plays an important role in BMP9-mediated osteoblast differentiation by promoting SMAD1/5 phosphorylation.
Autorzy :
Chiba N; Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.
Noguchi Y; Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.
Seong CH; Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.; Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.
Ohnishi T; Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.
Matsuguchi T; Department of Oral Biochemistry, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.
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Źródło :
FEBS letters [FEBS Lett] 2022 Jul; Vol. 596 (13), pp. 1720-1732. Date of Electronic Publication: 2022 Jun 01.
Typ publikacji :
Journal Article
MeSH Terms :
Growth Differentiation Factor 2*/metabolism
Signal Transduction*
Cell Differentiation ; Cell Line ; Osteoblasts ; Osteogenesis/genetics ; Phosphorylation ; Smad Proteins/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Rapid responses: Receptor-like kinases directly regulate the functions of membrane transport proteins in plants.
Autorzy :
Li X; Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
Zhang J; Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
Shi H; Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China.
Li B; Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
Li J; Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.; Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China.
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Źródło :
Journal of integrative plant biology [J Integr Plant Biol] 2022 Jul; Vol. 64 (7), pp. 1303-1309. Date of Electronic Publication: 2022 Jun 09.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Membrane Transport Proteins*/metabolism
Signal Transduction*/physiology
Plant Proteins/genetics ; Plant Proteins/metabolism ; Plants/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Vitexin-2-O-rhamnoside improves immunosuppression, oxidative stress, and phosphorylation of PI3K/Akt signal pathway in cyclophosphamide treated mice.
Autorzy :
Wang Y; College of Food Science and Engineering, Jinzhou Medical University, Jinzhou, 121000, Liaoning Province, China.
Ni W; College of Food Science and Engineering, Jinzhou Medical College, Jinzhou, 121013, Liaoning Province, China.
Jin X; College of Food Science and Engineering, Jinzhou Medical University, Jinzhou, 121000, Liaoning Province, China.
Li J; College of Veterinary, Jinzhou Medical University, Jinzhou, 121000, Liaoning Province, China.
Yu Y; College of Food Science and Engineering, Jinzhou Medical University, Jinzhou, 121000, Liaoning Province, China. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2022 Jun 15; Vol. 925, pp. 174999. Date of Electronic Publication: 2022 May 04.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants*/metabolism
Antioxidants*/pharmacology
Immunocompromised Host*/drug effects
Immunocompromised Host*/physiology
Immunosuppression Therapy*/adverse effects
Signal Transduction*/drug effects
Signal Transduction*/physiology
Animals ; Catalase/metabolism ; Cyclophosphamide/adverse effects ; Cyclophosphamide/pharmacology ; Flavonoids/pharmacology ; Glycosides/pharmacology ; Mice ; Oxidative Stress/drug effects ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Neurodegeneration and regeneration: Antioxidants and redox signaling.
Autorzy :
Zarkovic N; Laboratory for Oxidative Stress-LabOS, Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, HR, 10000, Zagreb, Croatia. Electronic address: .
Butterfield DA; Department of Chemistry and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40506, United States. Electronic address: .
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Źródło :
Free radical biology & medicine [Free Radic Biol Med] 2022 Aug 20; Vol. 189, pp. 154-156. Date of Electronic Publication: 2022 Aug 01.
Typ publikacji :
Editorial
MeSH Terms :
Antioxidants*/metabolism
Signal Transduction*
Oxidation-Reduction ; Oxidative Stress
Opinia redakcyjna
Szczegóły
Podgląd okładki
Tytuł :
BMP4 signaling plays critical roles in self-renewal of R2i mouse embryonic stem cells.
Autorzy :
Taleahmad S; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Salari A; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Samadian A; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Chae SH; Korea Brain Bank, Korea Brain Research Institute, Daegu, Republic of Korea.
Hwang D; School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Lee B; Lee Gil Ya Cancer and Diabetes Institute, School of Medicine, Gachon University, Incheon, Republic of Korea.
Bayarsaikhan D; Lee Gil Ya Cancer and Diabetes Institute, School of Medicine, Gachon University, Incheon, Republic of Korea.
Bayarsaikhan G; Lee Gil Ya Cancer and Diabetes Institute, School of Medicine, Gachon University, Incheon, Republic of Korea.
Lee J; Department of Chemistry, Seoul National University, Seoul, Republic of Korea.
Park JH; Department of Chemistry, Seoul National University, Seoul, Republic of Korea.
Hassani SN; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Baharvand H; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Developmental Biology, School of Basic Sciences and Advanced Technologies in Biology, University of Science and Culture, Tehran, Iran. Electronic address: .
Hosseini Salekdeh G; Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Aug 20; Vol. 617 (Pt 1), pp. 8-15. Date of Electronic Publication: 2022 May 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Mouse Embryonic Stem Cells*/metabolism
Signal Transduction*
Animals ; Bone Morphogenetic Protein 4/metabolism ; Bone Morphogenetic Proteins/metabolism ; Cell Differentiation ; MAP Kinase Signaling System ; Mice ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Kinetic Regulation of the Mammalian Sterile 20-like Kinase 2 (MST2).
Autorzy :
Koehler TJ; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States.
Tran T; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States.
Weingartner KA; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States.
Kavran JM; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States.; Department of Biophysics and Biophysical Chemistry, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, United States.; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, United States.
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Źródło :
Biochemistry [Biochemistry] 2022 Aug 16; Vol. 61 (16), pp. 1683-1693. Date of Electronic Publication: 2022 Jul 27.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Serine-Threonine Kinases*
Signal Transduction*
Animals ; Caspases/metabolism ; Kinetics ; Mammals/metabolism ; Phosphorylation
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Molecular and Structural Basis of Receptor Binding and Signaling of a Fish Type I IFN with Three Disulfide Bonds.
Autorzy :
Chen J; Key Laboratory of Marine Biotechnology of Fujian Province, College of Marine Sciences, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Guan Y; Key Laboratory of Marine Biotechnology of Fujian Province, College of Marine Sciences, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Guan H; Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, China.
Mu Y; Key Laboratory of Marine Biotechnology of Fujian Province, College of Marine Sciences, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Ding Y; Key Laboratory of Marine Biotechnology of Fujian Province, College of Marine Sciences, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.
Zou J; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, China; and.
Ouyang S; Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, China; .
Chen X; Key Laboratory of Marine Biotechnology of Fujian Province, College of Marine Sciences, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China; .; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, China.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Aug 15; Vol. 209 (4), pp. 806-819. Date of Electronic Publication: 2022 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Perciformes*
Signal Transduction*
Animals ; Antiviral Agents ; Disulfides/metabolism ; Fishes/metabolism ; Humans ; Janus Kinases/metabolism ; Mammals/metabolism ; Receptor, Interferon alpha-beta/metabolism ; STAT Transcription Factors/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development.
Autorzy :
Gillnäs S; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-75185 Uppsala, Sweden.
Gallini R; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-75185 Uppsala, Sweden.
He L; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-75185 Uppsala, Sweden.
Betsholtz C; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-75185 Uppsala, Sweden.
Andrae J; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjölds väg 20, SE-75185 Uppsala, Sweden.
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Źródło :
Biology open [Biol Open] 2022 Aug 15; Vol. 11 (8). Date of Electronic Publication: 2022 Aug 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Nervous System Malformations*/genetics
Signal Transduction*
Cerebellum/*growth & development
Platelet-Derived Growth Factor/*genetics
Receptor, Platelet-Derived Growth Factor alpha/*genetics
Animals ; Dandy-Walker Syndrome/diagnosis ; Dandy-Walker Syndrome/genetics ; Humans ; Lymphokines ; Mice
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Infection-induced membrane ruffling initiates danger and immune signaling via the mechanosensor PIEZO1.
Autorzy :
Tadala L; The Laboratory for Molecular Infection Medicine Sweden (MIMS), 901 87, Umeå, Sweden; Umeå Centre for Microbial Research (UCMR), 901 87 Umeå, Sweden; Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.
Langenbach D; The Laboratory for Molecular Infection Medicine Sweden (MIMS), 901 87, Umeå, Sweden; Umeå Centre for Microbial Research (UCMR), 901 87 Umeå, Sweden; Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.
Dannborg M; The Laboratory for Molecular Infection Medicine Sweden (MIMS), 901 87, Umeå, Sweden; Umeå Centre for Microbial Research (UCMR), 901 87 Umeå, Sweden; Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.
Cervantes-Rivera R; The Laboratory for Molecular Infection Medicine Sweden (MIMS), 901 87, Umeå, Sweden; Umeå Centre for Microbial Research (UCMR), 901 87 Umeå, Sweden; Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.
Sharma A; The Laboratory for Molecular Infection Medicine Sweden (MIMS), 901 87, Umeå, Sweden; Umeå Centre for Microbial Research (UCMR), 901 87 Umeå, Sweden; Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.
Vieth K; The Laboratory for Molecular Infection Medicine Sweden (MIMS), 901 87, Umeå, Sweden; Umeå Centre for Microbial Research (UCMR), 901 87 Umeå, Sweden; Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.
Rieckmann LM; The Laboratory for Molecular Infection Medicine Sweden (MIMS), 901 87, Umeå, Sweden; Umeå Centre for Microbial Research (UCMR), 901 87 Umeå, Sweden; Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.
Wanders A; Department of Medical Biosciences, Umeå University, 901 87 Umeå, Sweden; Department of Pathology, Aalborg University Hospital, 9100 Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark.
Cisneros DA; Umeå Centre for Microbial Research (UCMR), 901 87 Umeå, Sweden; Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.
Puhar A; The Laboratory for Molecular Infection Medicine Sweden (MIMS), 901 87, Umeå, Sweden; Umeå Centre for Microbial Research (UCMR), 901 87 Umeå, Sweden; Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2022 Aug 09; Vol. 40 (6), pp. 111173.
Typ publikacji :
Journal Article
MeSH Terms :
Ion Channels*/metabolism
Signal Transduction*
Adenosine Triphosphate/metabolism ; Biological Transport ; Cell Membrane/metabolism ; Mechanotransduction, Cellular/physiology
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling.
Autorzy :
Cui H; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China. .; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China. .; Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, 518005, China. .
Yi H; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
Bao H; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.; Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
Tan Y; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
Tian C; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
Shi X; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
Gan D; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
Zhang B; Computational Bioscience Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
Liang W; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
Chen R; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
Zhu Q; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
Fang L; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.; Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, 518005, China.
Gao X; Computational Bioscience Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
Huang H; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.; Key Laboratory of Molecular Design for Plant Cell Factory of Guangdong Higher Education Institutes, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
Tian R; Department of Chemistry, School of Science, Southern University of Science and Technology, Shenzhen, 518005, China.
Sperling SR; Cardiovascular Genetics, Charité-Universitätsmedizin Berlin, 13125, Berlin, Germany.
Hu Y; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China.
Chen W; Shenzhen Key Laboratory of Gene Regulation and Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China. .; Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518005, China. .; Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, 518005, China. .
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Źródło :
Nature communications [Nat Commun] 2022 Aug 09; Vol. 13 (1), pp. 4680. Date of Electronic Publication: 2022 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Renal Cell*/genetics
Kidney Neoplasms*/genetics
Signal Transduction*
Chromatin ; Chromatin Assembly and Disassembly ; DNA-Binding Proteins/metabolism ; Genome-Wide Association Study ; Humans ; Transcription Factors/metabolism ; Transforming Growth Factor beta/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains.
Autorzy :
Lu L; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Nanning, 530004, PR China. .; Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Center for Synthetic and Systems Biology, State Key Laboratory of Chemical Oncogenomics (Shenzhen), Department of Chemistry, Tsinghua University, Beijing, 100084, PR China. .
Zhai X; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Nanning, 530004, PR China.
Li X; Key Laboratory of Molecular Medicine and Biotherapy in the Ministry of Industry and Information Technology, Department of Biology, School of Life Science, Beijing Institute of Technology, Beijing, 100081, PR China.
Wang S; Shanxi Key Laboratory of Minor Crops Germplasm Innovation and Molecular Breeding, Shanxi Agricultural University, Taiyuan, 030031, PR China.; The State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, PR China.
Zhang L; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Nanning, 530004, PR China.
Wang L; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Nanning, 530004, PR China.
Jin X; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Nanning, 530004, PR China.
Liang L; Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Center for Synthetic and Systems Biology, State Key Laboratory of Chemical Oncogenomics (Shenzhen), Department of Chemistry, Tsinghua University, Beijing, 100084, PR China.
Deng Z; Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Center for Synthetic and Systems Biology, State Key Laboratory of Chemical Oncogenomics (Shenzhen), Department of Chemistry, Tsinghua University, Beijing, 100084, PR China.
Li Z; Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Center for Synthetic and Systems Biology, State Key Laboratory of Chemical Oncogenomics (Shenzhen), Department of Chemistry, Tsinghua University, Beijing, 100084, PR China.
Wang Y; Key Laboratory of Molecular Medicine and Biotherapy in the Ministry of Industry and Information Technology, Department of Biology, School of Life Science, Beijing Institute of Technology, Beijing, 100081, PR China.
Fu X; The State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, PR China.
Hu H; Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Center for Synthetic and Systems Biology, State Key Laboratory of Chemical Oncogenomics (Shenzhen), Department of Chemistry, Tsinghua University, Beijing, 100084, PR China.; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, PR China.
Wang J; State Key Laboratory of Membrane Biology, Tsinghua University, Beijing, 100084, PR China.
Mei Z; School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, PR China. .
He Z; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University, Nanning, 530004, PR China. .
Wang F; Key Laboratory of Molecular Medicine and Biotherapy in the Ministry of Industry and Information Technology, Department of Biology, School of Life Science, Beijing Institute of Technology, Beijing, 100081, PR China. .
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Źródło :
Nature communications [Nat Commun] 2022 Aug 09; Vol. 13 (1), pp. 4672. Date of Electronic Publication: 2022 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Oryza*/genetics
Oryza*/metabolism
Signal Transduction*
Deubiquitinating Enzymes/*metabolism
Animals ; Humans ; Mammals/metabolism ; Ubiquitin/metabolism ; Ubiquitination
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
CircKPNB1 mediates a positive feedback loop and promotes the malignant phenotypes of GSCs via TNF-α/NF-κB signaling.
Autorzy :
Jiang Y; Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
Zhao J; Department of Neurosurgery, Taihe Affiliated Hospital of Hubei University of Medicine, Shiyan, 442000, China.
Liu Y; Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
Hu J; Department of Neurosurgery, Taihe Affiliated Hospital of Hubei University of Medicine, Shiyan, 442000, China.
Gao L; Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.
Wang H; Department of Neurosurgery, Taihe Affiliated Hospital of Hubei University of Medicine, Shiyan, 442000, China. .
Cui D; Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China. damingcui_.
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Źródło :
Cell death & disease [Cell Death Dis] 2022 Aug 09; Vol. 13 (8), pp. 697. Date of Electronic Publication: 2022 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Neoplasms*/pathology
Glioblastoma*/pathology
Glioma*/pathology
MicroRNAs*/genetics
Signal Transduction*
beta Karyopherins/*genetics
Cell Line, Tumor ; Cell Proliferation ; Feedback ; Gene Expression Regulation, Neoplastic ; Humans ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Neoplastic Stem Cells/metabolism ; RNA-Binding Proteins/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Tumor Necrosis Factor-alpha/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
SESN2 prevents the slow-to-fast myofiber shift in denervated atrophy via AMPK/PGC-1α pathway.
Autorzy :
Yang X; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Xue P; Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Liu Z; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Li W; Department of Hand and Foot Surgery, Union Shenzhen Hospital, Huazhong University of Science and Technology, Shenzhen, 518052, China.
Li C; Department of Hand and Foot Surgery, Union Shenzhen Hospital, Huazhong University of Science and Technology, Shenzhen, 518052, China.
Chen Z; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. .
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Źródło :
Cellular & molecular biology letters [Cell Mol Biol Lett] 2022 Aug 09; Vol. 27 (1), pp. 66. Date of Electronic Publication: 2022 Aug 09.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Muscular Atrophy/*metabolism
Sestrins/*metabolism
AMP-Activated Protein Kinases/metabolism ; Animals ; Mice ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscular Atrophy/etiology ; Muscular Atrophy/pathology ; Rotenone/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Functional modulation of PTH1R activation and signaling by RAMP2.
Autorzy :
Nemec K; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
Schihada H; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.; Section of Receptor Biology & Signalling, Department of Physiology & Pharmacology, Karolinska Institute, S17177 Stockholm, Sweden.
Kleinau G; Group Protein X-Ray Crystallography and Signal Transduction, Institute of Medical Physics and Biophysics, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.
Zabel U; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
Grushevskyi EO; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
Scheerer P; Group Protein X-Ray Crystallography and Signal Transduction, Institute of Medical Physics and Biophysics, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung, 10785 Berlin, Germany.
Lohse MJ; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.; ISAR Bioscience Institute, 82152 Planegg/Munich, Germany.
Maiellaro I; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.; School of Life Sciences, Queen's Medical Centre, University of Nottingham, NG7 2UH Nottingham, United Kingdom.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Aug 09; Vol. 119 (32), pp. e2122037119. Date of Electronic Publication: 2022 Aug 01.
Typ publikacji :
Journal Article
MeSH Terms :
Receptor Activity-Modifying Protein 2*/genetics
Receptor Activity-Modifying Protein 2*/metabolism
Receptor, Parathyroid Hormone, Type 1*/genetics
Receptor, Parathyroid Hormone, Type 1*/metabolism
Signal Transduction*
Biosensing Techniques ; Ligands ; Parathyroid Hormone/metabolism ; Receptors, G-Protein-Coupled/metabolism ; beta-Arrestin 2/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody.
Autorzy :
Baidya M; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, 208016, India.
Chaturvedi M; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, 208016, India.
Dwivedi-Agnihotri H; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, 208016, India.
Ranjan A; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, 208016, India.
Devost D; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, H3G 1Y6, Canada.
Namkung Y; Department of Medicine, McGill University Health Center, McGill University, Montréal, QC, H4A 3J1, Canada.
Stepniewski TM; Research Program on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), 08003, Barcelona, Spain.; Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, Warsaw, Poland.
Pandey S; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, 208016, India.
Baruah M; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, 208016, India.
Panigrahi B; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, 208016, India.
Sarma P; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, 208016, India.
Yadav MK; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, 208016, India.
Maharana J; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, 208016, India.
Banerjee R; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, 208016, India.
Kawakami K; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.
Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.
Selent J; Research Program on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences of Pompeu Fabra University (UPF)-Hospital del Mar Medical Research Institute (IMIM), 08003, Barcelona, Spain.
Laporte SA; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, H3G 1Y6, Canada.; Department of Medicine, McGill University Health Center, McGill University, Montréal, QC, H4A 3J1, Canada.
Hébert TE; Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, H3G 1Y6, Canada.
Shukla AK; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, 208016, India. .
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Źródło :
Nature communications [Nat Commun] 2022 Aug 08; Vol. 13 (1), pp. 4634. Date of Electronic Publication: 2022 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Receptors, G-Protein-Coupled*/metabolism
Signal Transduction*
Phosphorylation ; beta-Arrestin 1/genetics ; beta-Arrestin 1/metabolism ; beta-Arrestin 2/metabolism ; beta-Arrestins/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity.
Autorzy :
Mota-Martorell N; Department of Experimental Medicine, University of Lleida, Lleida Biomedical Research Institute (UdL-IRBLleida), E-25198 Lleida, Spain.
Jové M; Department of Experimental Medicine, University of Lleida, Lleida Biomedical Research Institute (UdL-IRBLleida), E-25198 Lleida, Spain.
Pamplona R; Department of Experimental Medicine, University of Lleida, Lleida Biomedical Research Institute (UdL-IRBLleida), E-25198 Lleida, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2022 Aug 06; Vol. 23 (15). Date of Electronic Publication: 2022 Aug 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Longevity*
Signal Transduction*/physiology
Animals ; Humans ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Sirolimus ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Szczegóły
Podgląd okładki
Tytuł :
The role of sex in exhaustion.
Autorzy :
Henrickson SE; Children's Hospital of Philadelphia, Division of Allergy Immunology, Department of Pediatrics, and Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Email: .
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Źródło :
Science immunology [Sci Immunol] 2022 Aug 05; Vol. 7 (74), pp. eade1495. Date of Electronic Publication: 2022 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
CD8-Positive T-Lymphocytes*
Signal Transduction*
Czasopismo naukowe
Szczegóły
Wyświetlanie 1-20 z 1057499

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