Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ
Zmień bibliotekę

Wyszukujesz frazę ""Tumbrink HL"" wg kryterium: Autor


Wyświetlanie 1-13 z 13
Tytuł :
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.
Autorzy :
Lategahn J; PearlRiver Bio GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Tumbrink HL; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Schultz-Fademrecht C; PearlRiver Bio GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
Heimsoeth A; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Werr L; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Niggenaber J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Keul M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Parmaksiz F; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Baumann M; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
Menninger S; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
Zent E; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
Landel I; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Weisner J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Jeyakumar K; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Heyden L; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Russ N; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Müller F; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Lorenz C; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Brägelmann J; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.; Mildred Scheel School of Oncology Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Spille I; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Grabe T; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Müller MP; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Heuckmann JM; PearlRiver Bio GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
Klebl BM; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.; The Norwegian College of Fishery Science, UiT The Arctic University of Norway, PO Box 6050 Langnes, N-9037 Tromsø, Norway.
Nussbaumer P; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
Sos ML; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2022 May 12; Vol. 65 (9), pp. 6643-6655. Date of Electronic Publication: 2022 Apr 29.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/drug therapy
Lung Neoplasms*/genetics
Lung Neoplasms*/pathology
Animals ; Humans ; Mice ; Mutagenesis, Insertional ; Mutation ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł :
CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization.
Autorzy :
Werr L; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Plenker D; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Dammert MA; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Lorenz C; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Brägelmann J; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; Mildred Scheel School of Oncology, Cologne, University Hospital Cologne, Medical Faculty, Cologne, Germany.
Tumbrink HL; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Klein S; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.
Schmitt A; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Büttner R; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.
Persigehl T; Department of Radiology, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.
Shokat KM; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California.
Wunderlich FT; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; Max Planck Institute for Metabolism Research, Cologne, Germany.; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne, Cologne, Germany.
Schram AM; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Medical College, New York, New York.
Peifer M; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Sos ML; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
Reinhardt HC; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, German Cancer Consortium (DKTK partner site Essen), Essen, Germany.
Thomas RK; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; DKFZ, German Cancer Research Center, German Cancer Consortium (DKTK), Heidelberg, Germany.
Pokaż więcej
Źródło :
Molecular cancer therapeutics [Mol Cancer Ther] 2022 May 04; Vol. 21 (5), pp. 821-830.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma of Lung*
Lung Neoplasms*
Animals ; Carcinogenesis/genetics ; Humans ; Mice ; Neuregulin-1/genetics ; Oncogenes ; Receptor, ErbB-2/genetics ; Receptor, ErbB-3/genetics
Czasopismo naukowe
Tytuł :
Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer.
Autorzy :
Schaufler D; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Network Genomic Medicine, Lung Cancer Group Cologne, Cologne, Germany.
Ast DF; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Molecular Pathology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; Mildred Scheel School of Oncology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Tumbrink HL; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Molecular Pathology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.
Abedpour N; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne, Cologne, Germany.
Maas L; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.
Schwäbe AE; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Molecular Pathology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.
Spille I; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Molecular Pathology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.
Lennartz S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Molecular Pathology, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.
Fassunke J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Network Genomic Medicine, Cologne, Germany.
Aldea M; Department of medical oncology, Thoracic Group, Gustave Roussy, Villejuif, Paris Sud University Orsay, Paris, France.
Besse B; Department of medical oncology, Thoracic Group, Gustave Roussy, Villejuif, Paris Sud University Orsay, Paris, France.
Planchard D; Department of medical oncology, Thoracic Group, Gustave Roussy, Villejuif, Paris Sud University Orsay, Paris, France.
Nogova L; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Network Genomic Medicine, Lung Cancer Group Cologne, Cologne, Germany.
Michels S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Network Genomic Medicine, Lung Cancer Group Cologne, Cologne, Germany.
Kobe C; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Nuclear Medicine, Cologne, Germany.
Persigehl T; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Diagnostic and Interventional Radiology, Cologne, Germany.
Westphal T; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Network Genomic Medicine, Lung Cancer Group Cologne, Cologne, Germany.
Koleczko S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Network Genomic Medicine, Lung Cancer Group Cologne, Cologne, Germany.
Fischer R; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Network Genomic Medicine, Lung Cancer Group Cologne, Cologne, Germany.
Weber JP; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Network Genomic Medicine, Lung Cancer Group Cologne, Cologne, Germany.
Altmüller J; Cologne Center for Genomics, University of Cologne, Cologne, Germany.
Thomas RK; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Network Genomic Medicine, Cologne, Germany.; DKFZ, German Cancer Research Center, German Cancer Consortium (DKTK), Heidelberg, Germany.
Merkelbach-Bruse S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Network Genomic Medicine, Cologne, Germany.
Gautschi O; University of Bern and Cantonal Hospital of Lucerne, Lucerne, Switzerland.
Mezquita L; Medical Oncology Department, Hospital Clinic, Laboratory of Translational Genomics and Targeted therapies in Solid Tumors, IDIBAPS, Barcelona, Spain.
Büttner R; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Network Genomic Medicine, Cologne, Germany.
Wolf J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Network Genomic Medicine, Lung Cancer Group Cologne, Cologne, Germany.
Peifer M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.
Brägelmann J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Molecular Pathology, Cologne, Germany. .; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany. .; Mildred Scheel School of Oncology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. .; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne, Cologne, Germany. .
Scheffler M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Network Genomic Medicine, Lung Cancer Group Cologne, Cologne, Germany. .
Sos ML; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Molecular Pathology, Cologne, Germany. .; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany. .; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne, Cologne, Germany. .
Pokaż więcej
Źródło :
NPJ precision oncology [NPJ Precis Oncol] 2021 Dec 17; Vol. 5 (1), pp. 102. Date of Electronic Publication: 2021 Dec 17.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes.
Autorzy :
Bebber CM; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Clinic I for Internal Medicine, Medical Faculty, University Hospital of Cologne, Cologne, Germany.
Thomas ES; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Imperial College London, London, UK.
Stroh J; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.
Chen Z; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.
Androulidaki A; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.
Schmitt A; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Clinic I for Internal Medicine, Medical Faculty, University Hospital of Cologne, Cologne, Germany.
Höhne MN; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Department for Chemistry, Institute for Biochemistry, University of Cologne, Cologne, Germany.
Stüker L; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.
de Pádua Alves C; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.
Khonsari A; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany.
Dammert MA; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany.
Parmaksiz F; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany.
Tumbrink HL; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany.
Beleggia F; Clinic I for Internal Medicine, Medical Faculty, University Hospital of Cologne, Cologne, Germany.
Sos ML; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany.
Riemer J; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Department for Chemistry, Institute for Biochemistry, University of Cologne, Cologne, Germany.
George J; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.
Brodesser S; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.
Thomas RK; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; DKFZ, German Cancer Research Center, German Cancer Consortium (DKTK), Heidelberg, Germany.
Reinhardt HC; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, German Cancer Consortium (DKTK partner site Essen), Essen, Germany.
von Karstedt S; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany. .; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany. .; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Apr 06; Vol. 12 (1), pp. 2048. Date of Electronic Publication: 2021 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Ferroptosis*
Neuroendocrine Tumors/*pathology
Small Cell Lung Carcinoma/*pathology
Animals ; Antioxidants/metabolism ; Apoptosis ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Cell Survival ; Humans ; Lipid Metabolism ; Male ; Mice, Nude ; Models, Biological ; Necroptosis ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Phospholipids/metabolism ; Prognosis ; Thioredoxins/metabolism
Czasopismo naukowe
Tytuł :
The next tier of EGFR resistance mutations in lung cancer.
Autorzy :
Tumbrink HL; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne‑Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.
Heimsoeth A; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne‑Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.
Sos ML; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany. .; Department of Translational Genomics, Center of Integrated Oncology Cologne‑Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany. .; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany. .
Pokaż więcej
Źródło :
Oncogene [Oncogene] 2021 Jan; Vol. 40 (1), pp. 1-11. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Drug Resistance, Neoplasm*
Mutation*
Adenocarcinoma of Lung/*genetics
Lung Neoplasms/*genetics
Adenocarcinoma of Lung/drug therapy ; ErbB Receptors/chemistry ; ErbB Receptors/genetics ; Humans ; Lung Neoplasms/drug therapy ; Models, Molecular ; Protein Conformation ; Protein Domains ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł :
Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach.
Autorzy :
Lategahn J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Hardick J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Grabe T; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Niggenaber J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Jeyakumar K; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Keul M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Tumbrink HL; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.
Becker C; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.
Hodson L; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, 7602 Matieland, South Africa.
Kirschner T; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Klövekorn P; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.
Ketzer J; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, Medical School, University Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Baumann M; Lead Discovery Center GmbH, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany.
Terheyden S; Lead Discovery Center GmbH, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany.
Unger A; Lead Discovery Center GmbH, Otto-Hahn-Strasse 15, 44227 Dortmund, Germany.
Weisner J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Müller MP; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
van Otterlo WAL; Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, 7602 Matieland, South Africa.
Bauer S; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, Medical School, University Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany.; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Oct 22; Vol. 63 (20), pp. 11725-11755. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Design*
Protein Kinase Inhibitors/*pharmacology
Pyrimidines/*pharmacology
Pyrroles/*pharmacology
Receptor, ErbB-2/*antagonists & inhibitors
Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Humans ; Kinetics ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Pyrroles/chemical synthesis ; Pyrroles/chemistry ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/isolation & purification ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.
Autorzy :
Lategahn J; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.; Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW) , 44227 Dortmund , Germany.
Keul M; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.; Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW) , 44227 Dortmund , Germany.
Klövekorn P; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.
Tumbrink HL; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.
Niggenaber J; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.; Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW) , 44227 Dortmund , Germany.
Müller MP; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.; Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW) , 44227 Dortmund , Germany.
Hodson L; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.; Department of Chemistry and Polymer Science , Stellenbosch University , Private Bag X1 , Matieland 7602 , South Africa.
Flaßhoff M; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.
Hardick J; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.; Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW) , 44227 Dortmund , Germany.
Grabe T; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.; Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW) , 44227 Dortmund , Germany.
Engel J; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.
Schultz-Fademrecht C; Lead Discovery Center GmbH , Otto-Hahn-Strasse 15 , 44227 Dortmund , Germany.
Baumann M; Lead Discovery Center GmbH , Otto-Hahn-Strasse 15 , 44227 Dortmund , Germany.
Ketzer J; Department of Medical Oncology , Sarcoma Center , West German Cancer Center , University Duisburg-Essen , Medical School , Hufelandstrasse 55 , 45122 Essen , Germany.; German Cancer Consortium (DKTK) , 69120, Heidelberg , Germany.
Mühlenberg T; Department of Medical Oncology , Sarcoma Center , West German Cancer Center , University Duisburg-Essen , Medical School , Hufelandstrasse 55 , 45122 Essen , Germany.; German Cancer Consortium (DKTK) , 69120, Heidelberg , Germany.
Hiller W; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.
Günther G; Leibniz Research Centre for Working Environment and Human Factors (IfADo) , TU Dortmund University , Ardeystrasse 67 , 44139 Dortmund , Germany.
Unger A; Lead Discovery Center GmbH , Otto-Hahn-Strasse 15 , 44227 Dortmund , Germany.
Müller H; Lead Discovery Center GmbH , Otto-Hahn-Strasse 15 , 44227 Dortmund , Germany.
Heimsoeth A; Molecular Pathology , Institute of Pathology , University Hospital of Cologne , Kerpener Strasse 62 , 50937 Cologne , Germany.; Department of Translational Genomics , Center of Integrated Oncology Cologne-Bonn , Medical Faculty , University of Cologne , Weyertal 115b , 50931 Cologne , Germany.
Golz C; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.
Blank-Landeshammer B; Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. , Otto-Hahn-Strasse 6b , 44227 Dortmund , Germany.
Kollipara L; Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. , Otto-Hahn-Strasse 6b , 44227 Dortmund , Germany.
Zahedi RP; Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. , Otto-Hahn-Strasse 6b , 44227 Dortmund , Germany.; Segal Cancer Proteomics Centre , Lady Davis Institute , Jewish General Hospital , McGill University , 3755 Côte Ste-Catherine Road , Montreal , Quebec H3T 1E2 , Canada.
Strohmann C; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.
Hengstler JG; Leibniz Research Centre for Working Environment and Human Factors (IfADo) , TU Dortmund University , Ardeystrasse 67 , 44139 Dortmund , Germany.
van Otterlo WAL; Department of Chemistry and Polymer Science , Stellenbosch University , Private Bag X1 , Matieland 7602 , South Africa.
Bauer S; Department of Medical Oncology , Sarcoma Center , West German Cancer Center , University Duisburg-Essen , Medical School , Hufelandstrasse 55 , 45122 Essen , Germany.; German Cancer Consortium (DKTK) , 69120, Heidelberg , Germany.
Rauh D; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany . Email: ; www.twitter.com/DDHDortmund ; Tel: +49-231-755-7080.; Drug Discovery Hub Dortmund (DDHD), Zentrum für Integrierte Wirkstoffforschung (ZIW) , 44227 Dortmund , Germany.
Pokaż więcej
Źródło :
Chemical science [Chem Sci] 2019 Oct 04; Vol. 10 (46), pp. 10789-10801. Date of Electronic Publication: 2019 Oct 04 (Print Publication: 2019).
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer.
Autorzy :
Dammert MA; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.
Brägelmann J; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, 50931, Cologne, Germany.
Olsen RR; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA.
Böhm S; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.
Monhasery N; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.
Whitney CP; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA.
Chalishazar MD; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA.
Tumbrink HL; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.
Guthrie MR; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA.
Klein S; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, 50931, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.
Ireland AS; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA.
Ryan J; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA.
Schmitt A; Department I of Internal Medicine, University Hospital of Cologne, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, 50931, Cologne, Germany.
Marx A; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.
Ozretić L; Department of Cellular Pathology, Royal Free Hospital, London, NW3 2QG, UK.
Castiglione R; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, 50931, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.
Lorenz C; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.
Jachimowicz RD; Department I of Internal Medicine, University Hospital of Cologne, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, 50931, Cologne, Germany.
Wolf E; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany.
Thomas RK; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.
Poirier JT; Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Büttner R; Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.
Sen T; Department of Thoracic and Head & Neck Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, 77030, USA.
Byers LA; Department of Thoracic and Head & Neck Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, 77030, USA.
Reinhardt HC; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, 50931, Cologne, Germany.; Department I of Internal Medicine, University Hospital of Cologne, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, 50931, Cologne, Germany.
Letai A; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA.
Oliver TG; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA. .
Sos ML; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany. .; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany. .; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2019 Aug 02; Vol. 10 (1), pp. 3485. Date of Electronic Publication: 2019 Aug 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*genetics
Gene Expression Regulation, Neoplastic/*genetics
Lung Neoplasms/*genetics
Proto-Oncogene Proteins c-myc/*metabolism
Small Cell Lung Carcinoma/*genetics
Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; CRISPR-Cas Systems/genetics ; Cell Line, Tumor ; DNA Damage/drug effects ; DNA Damage/genetics ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic/drug effects ; HEK293 Cells ; Humans ; Lung Neoplasms/drug therapy ; Mice ; Molecular Targeted Therapy/methods ; Proto-Oncogene Proteins c-myc/genetics ; RNA, Small Interfering/metabolism ; Small Cell Lung Carcinoma/drug therapy
Czasopismo naukowe
Tytuł :
Overcoming EGFR -mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors.
Autorzy :
Fassunke J; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Müller F; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany.
Keul M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227, Dortmund, Germany.
Michels S; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany.
Dammert MA; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany.
Schmitt A; Center for Molecular Medicine Cologne, University of Cologne, Robert-Koch-Str. 21, 50931, Cologne, Germany.; Department I of Internal Medicine, University Hospital of Cologne, Weyertal 115b, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Joseph Stelzmann Str. 26, 50931, Cologne, Germany.
Plenker D; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany.
Lategahn J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227, Dortmund, Germany.
Heydt C; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Brägelmann J; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany.
Tumbrink HL; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany.
Alber Y; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227, Dortmund, Germany.
Klein S; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany.; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Weyertal 115b, 50931, Cologne, Germany.
Heimsoeth A; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany.
Dahmen I; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany.
Fischer RN; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany.
Scheffler M; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany.
Ihle MA; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Priesner V; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany.
Scheel AH; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Wagener S; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Kron A; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany.
Frank K; Section Pneumology, Clinic III of Internal Medicine, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Garbert K; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany.
Persigehl T; Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Püsken M; Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Haneder S; Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Schaaf B; Hospital Dortmund gGmbH, Muensterstrasse 240, 44145, Dortmund, Germany.
Rodermann E; Onkologie Rhein-Sieg, Schloßstraße 18, 53840, Troisdorf, Germany.
Engel-Riedel W; Department of Pneumology, Lung Hospital Cologne Merheim, City of Cologne Municipal Hospitals, Cologne, Germany.
Felip E; Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
Smit EF; Thoracic Oncology Service, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Merkelbach-Bruse S; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Reinhardt HC; Center for Molecular Medicine Cologne, University of Cologne, Robert-Koch-Str. 21, 50931, Cologne, Germany.; Department I of Internal Medicine, University Hospital of Cologne, Weyertal 115b, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Joseph Stelzmann Str. 26, 50931, Cologne, Germany.
Kast SM; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227, Dortmund, Germany.
Wolf J; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany. .
Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227, Dortmund, Germany. .
Büttner R; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. .; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany. .; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany. .
Sos ML; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. .; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany. .; Center for Molecular Medicine Cologne, University of Cologne, Robert-Koch-Str. 21, 50931, Cologne, Germany. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2018 Nov 07; Vol. 9 (1), pp. 4655. Date of Electronic Publication: 2018 Nov 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Neoplasm/*drug effects
ErbB Receptors/*antagonists & inhibitors
Piperazines/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Acrylamides ; Aniline Compounds ; Animals ; Cell Line, Tumor ; Disease Progression ; ErbB Receptors/chemistry ; ErbB Receptors/metabolism ; Female ; Humans ; Kinetics ; Mice ; Mice, Nude ; Mutation/genetics ; NIH 3T3 Cells ; Piperazines/chemistry ; Protein Binding/drug effects ; Protein Conformation ; Protein Kinase Inhibitors/chemistry
Czasopismo naukowe
Tytuł :
Insights into the Kinetics of the Resistance Formation of Bacteria against Ciprofloxacin Poly(2-methyl-2-oxazoline) Conjugates.
Autorzy :
Schmidt M
Romanovska A
Wolf Y
Nguyen TD
Krupp A
Tumbrink HL; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany.
Lategahn J; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany.
Volmer J
Rauh D; Faculty of Chemistry and Chemical Biology , TU Dortmund University , Otto-Hahn-Strasse 4a , 44227 Dortmund , Germany.
Luetz S
Krumm C
Tiller JC
Pokaż więcej
Źródło :
Bioconjugate chemistry [Bioconjug Chem] 2018 Aug 15; Vol. 29 (8), pp. 2671-2678. Date of Electronic Publication: 2018 Jul 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Resistance, Bacterial*
Anti-Bacterial Agents/*chemistry
Anti-Bacterial Agents/*pharmacology
Ciprofloxacin/*chemistry
Ciprofloxacin/*pharmacology
Escherichia coli/*drug effects
Polyamines/*chemistry
Polyamines/*pharmacology
Staphylococcus aureus/*drug effects
Erythrocytes/drug effects ; Kinetics ; Microbial Sensitivity Tests
Czasopismo naukowe
Tytuł :
Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
Autorzy :
Engel J; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, D-44227 Dortmund, Germany.
Smith S; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, D-44227 Dortmund, Germany.
Lategahn J; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, D-44227 Dortmund, Germany.
Tumbrink HL; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, D-44227 Dortmund, Germany.
Goebel L; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, D-44227 Dortmund, Germany.
Becker C; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, D-44227 Dortmund, Germany.
Hennes E; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, D-44227 Dortmund, Germany.
Keul M; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, D-44227 Dortmund, Germany.
Unger A; Lead Discovery Center GmbH , Otto-Hahn-Straße 15, D-44227 Dortmund, Germany.
Müller H; Lead Discovery Center GmbH , Otto-Hahn-Straße 15, D-44227 Dortmund, Germany.
Baumann M; Lead Discovery Center GmbH , Otto-Hahn-Straße 15, D-44227 Dortmund, Germany.
Schultz-Fademrecht C; Lead Discovery Center GmbH , Otto-Hahn-Straße 15, D-44227 Dortmund, Germany.
Günther G; Leibniz Research Centre for Working Environment and Human Factors (IfADo), TU Dortmund University , D-44139 Dortmund, Germany.
Hengstler JG; Leibniz Research Centre for Working Environment and Human Factors (IfADo), TU Dortmund University , D-44139 Dortmund, Germany.
Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, D-44227 Dortmund, Germany.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2017 Sep 28; Vol. 60 (18), pp. 7725-7744. Date of Electronic Publication: 2017 Sep 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
ErbB Receptors/*antagonists & inhibitors
Lung Neoplasms/*drug therapy
Protein Kinase Inhibitors/*chemistry
Protein Kinase Inhibitors/*pharmacology
Animals ; Antineoplastic Agents/pharmacokinetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; ErbB Receptors/chemistry ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Male ; Mice ; Molecular Docking Simulation ; Point Mutation ; Protein Kinase Inhibitors/pharmacokinetics ; Pyrazoles/chemistry ; Pyrazoles/pharmacokinetics ; Pyrazoles/pharmacology ; Pyrimidines/chemistry ; Pyrimidines/pharmacokinetics ; Pyrimidines/pharmacology
Czasopismo naukowe
Tytuł :
Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.
Autorzy :
Günther M; Institute of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry, Eberhard Karls University Tübingen , Auf der Morgenstelle 8, 72076 Tübingen, Germany.
Lategahn J; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, 44227 Dortmund, Germany.
Juchum M; Institute of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry, Eberhard Karls University Tübingen , Auf der Morgenstelle 8, 72076 Tübingen, Germany.
Döring E; Institute of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry, Eberhard Karls University Tübingen , Auf der Morgenstelle 8, 72076 Tübingen, Germany.
Keul M; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, 44227 Dortmund, Germany.
Engel J; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, 44227 Dortmund, Germany.
Tumbrink HL; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, 44227 Dortmund, Germany.
Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, 44227 Dortmund, Germany.
Laufer S; Institute of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry, Eberhard Karls University Tübingen , Auf der Morgenstelle 8, 72076 Tübingen, Germany.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2017 Jul 13; Vol. 60 (13), pp. 5613-5637. Date of Electronic Publication: 2017 Jun 21.
Typ publikacji :
Journal Article
MeSH Terms :
ErbB Receptors/*antagonists & inhibitors
ErbB Receptors/*genetics
Imidazoles/*chemistry
Imidazoles/*pharmacology
Protein Kinase Inhibitors/*chemistry
Protein Kinase Inhibitors/*pharmacology
Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; ErbB Receptors/metabolism ; Gefitinib ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Molecular Docking Simulation ; Point Mutation ; Quinazolines/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.
Autorzy :
Tomassi S; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, Dortmund D-44227, Germany.
Lategahn J; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, Dortmund D-44227, Germany.
Engel J; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, Dortmund D-44227, Germany.
Keul M; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, Dortmund D-44227, Germany.
Tumbrink HL; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, Dortmund D-44227, Germany.
Ketzer J; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Duisburg-Essen , Medical School, Hufelandstraße 55, Essen D-45122, Germany.; German Cancer Consortium (DKTK) , Heidelberg D-69120, Germany.
Mühlenberg T; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Duisburg-Essen , Medical School, Hufelandstraße 55, Essen D-45122, Germany.; German Cancer Consortium (DKTK) , Heidelberg D-69120, Germany.
Baumann M; Lead Discovery Center GmbH , Otto-Hahn-Straße 15, Dortmund D-44227, Germany.
Schultz-Fademrecht C; Lead Discovery Center GmbH , Otto-Hahn-Straße 15, Dortmund D-44227, Germany.
Bauer S; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Duisburg-Essen , Medical School, Hufelandstraße 55, Essen D-45122, Germany.; German Cancer Consortium (DKTK) , Heidelberg D-69120, Germany.
Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University , Otto-Hahn-Straße 4a, Dortmund D-44227, Germany.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2017 Mar 23; Vol. 60 (6), pp. 2361-2372. Date of Electronic Publication: 2017 Mar 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Carcinoma, Non-Small-Cell Lung/*drug therapy
ErbB Receptors/*antagonists & inhibitors
Lung Neoplasms/*drug therapy
Animals ; Antineoplastic Agents/pharmacokinetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Cell Line, Tumor ; Drug Resistance, Neoplasm/drug effects ; ErbB Receptors/genetics ; Humans ; Indazoles ; Lung/drug effects ; Lung/metabolism ; Lung Neoplasms/genetics ; Mice ; Molecular Docking Simulation ; Mutation/drug effects ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacokinetics ; Protein Kinase Inhibitors/pharmacology
Czasopismo naukowe
    Wyświetlanie 1-13 z 13

    Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies