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Tytuł :
Down regulation and nuclear localization of human beta-defensin-1 in pleomorphic adenomas of salivary glands.
Autorzy :
Pantelis A; Department of Otorhinolaryngology/Surgery, University of Bonn, D-53105 Bonn, Germany. />Wenghoefer M
Haas S
Merkelbach-Bruse S
Pantelis D
Jepsen S
Bootz F
Winter J
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Źródło :
Oral oncology [Oral Oncol] 2009 Jun; Vol. 45 (6), pp. 526-30. Date of Electronic Publication: 2008 Sep 20.
Typ publikacji :
Journal Article
MeSH Terms :
Adenoma, Pleomorphic/*metabolism
Neoplasm Proteins/*metabolism
Salivary Gland Neoplasms/*metabolism
beta-Defensins/*metabolism
Adenoma, Pleomorphic/pathology ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Cell Nucleus/metabolism ; Chronic Disease ; Down-Regulation ; Female ; Humans ; Male ; Middle Aged ; Polymerase Chain Reaction/methods ; RNA, Messenger ; Salivary Gland Neoplasms/pathology ; Sialadenitis/metabolism ; Sialadenitis/pathology ; Young Adult
Czasopismo naukowe
Tytuł :
PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity, prognostic impact and incidence of prior malignancies.
Autorzy :
Scheffler M; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Bos M; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Gardizi M; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
König K; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Michels S; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Fassunke J; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Heydt C; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Künstlinger H; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Ihle M; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Ueckeroth F; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Albus K; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Serke M; Department for Pulmonology and Thoracic Oncology, Lung Clinic Hemer, Hemer, Germany.
Gerigk U; Clinic for Hematology, Oncology and Palliative Care, Malteser Hospital, Bonn, Germany.
Schulte W; Clinic for Hematology, Oncology and Palliative Care, Malteser Hospital, Bonn, Germany.
Töpelt K; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Nogova L; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Zander T; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Gastrointestinal Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Engel-Riedel W; Lung Clinic Merheim, Hospital of Cologne, Cologne, Germany.
Stoelben E; Lung Clinic Merheim, Hospital of Cologne, Cologne, Germany.
Ko YD; Johanniter Hospital, Evangelical Clinics of Bonn, Bonn, Germany.
Randerath W; Clinic for Pneumology and Allergology Center for Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany.
Kaminsky B; Clinic for Pneumology and Allergology Center for Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany.
Panse J; Department of Medicine IV, University Hospital RWTH Aachen, Aachen, Germany.
Becker C; Department of Medicine IV, University Hospital RWTH Aachen, Aachen, Germany.
Hellmich M; Institute of Medical Statistics, Informatics, and Epidemiology, University of Cologne, Cologne, Germany.
Merkelbach-Bruse S; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Heukamp LC; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Büttner R; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Wolf J; Center for Integrated Oncology Köln Bonn, Cologne, Germany.Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
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Źródło :
Oncotarget [Oncotarget] 2015 Jan 20; Vol. 6 (2), pp. 1315-26.
Typ publikacji :
Journal Article
MeSH Terms :
Mutation*
Carcinoma, Non-Small-Cell Lung/*genetics
Lung Neoplasms/*genetics
Phosphatidylinositol 3-Kinases/*genetics
Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/therapy ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/therapy ; Class I Phosphatidylinositol 3-Kinases ; Cohort Studies ; Exons/genetics ; Female ; Gene Frequency ; Genetic Heterogeneity ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Male ; Middle Aged ; Neoplasms, Second Primary/genetics ; Neoplasms, Second Primary/pathology ; Prognosis ; Survival Analysis
Czasopismo naukowe
Tytuł :
ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability.
Autorzy :
Scheffler M; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Schultheis A; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Teixido C; Pangaea Biotech, Quirón Dexeus University Hospital, Barcelona, Spain.
Michels S; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Morales-Espinosa D; Institut d'Investigació en Ciències de la Salut, Germans Trias i Pujol, Badalona, Spain.
Viteri S; Instituto Oncológico Dr Rosell, Quirón Dexeus University Hospital, Barcelona, Spain.
Hartmann W; Gerhard-Domagk-Institute of Pathology, University Hospital of Münster, Münster, Germany.
Merkelbach-Bruse S; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Fischer R; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
Schildhaus HU; Institute of Pathology, University Hospital of Göttingen, Göttingen, Germany.
Fassunke J; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Sebastian M; Department of Hematology/Oncology, University Hospital of Frankfurt, Frankfurt, Germany.
Serke M; Department for Pulmonology and Thoracic Oncology, Lung Clinic Hemer, Hemer, Germany.
Kaminsky B; Clinic for Pneumology and Allergology Center for Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany.
Randerath W; Clinic for Pneumology and Allergology Center for Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany.
Gerigk U; Thoracic Centre, Malteser Hospital Bonn/Rhein-Sieg, Bonn, Germany.
Ko YD; Johanniter Hospital, Evangelical Clinics of Bonn, Bonn, Germany.
Krüger S; Clinic for Pneumology/Allergology/Sleep Medicine and Respiratory Care, Florence-Nightingale-Hospital, Düsseldorf, Germany.
Schnell R; Practice for Internistic Oncology and Hematology, Frechen, Germany.
Rothe A; Practice for Hematology and Oncology Mainka/Dietze/Rothe, Cologne, Germany.
Kropf-Sanchen C; Department II for Internal Medicine, University Hospital of Ulm, Ulm, Germany.
Heukamp L; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Rosell R; Instituto Oncológico Dr Rosell, Quirón Dexeus University Hospital, Barcelona, Spain.; Cancer Biology and Precision Medicine Program, Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Badalona, Spain.; Molecular Oncology Research (MORe) Foundation, Barcelona, Spain.
Büttner R; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Wolf J; Center for Integrated Oncology Köln Bonn, Cologne, Germany.; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
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Źródło :
Oncotarget [Oncotarget] 2015 Apr 30; Vol. 6 (12), pp. 10577-85.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*genetics
Lung Neoplasms/*genetics
Protein-Tyrosine Kinases/*genetics
Proto-Oncogene Proteins/*genetics
Adenocarcinoma/drug therapy ; Adenocarcinoma/enzymology ; Adenocarcinoma of Lung ; Adult ; Aged ; Female ; Gene Rearrangement ; Genetic Variation ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/enzymology ; Male ; Middle Aged ; Prognosis ; Protein-Tyrosine Kinases/metabolism ; Proto-Oncogene Proteins/metabolism ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Spatial Tumor Heterogeneity in Lung Cancer with Acquired Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance: Targeting High-Level MET-Amplification and EGFR T790M Mutation Occurring at Different Sites in the Same Patient.
Autorzy :
Scheffler M; Lung Cancer Group Cologne, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; †Center for Integrated Oncology Köln Bonn, Institute of Pathology, University Hospital of Cologne, Cologne, Germany; ‡Department of Translational Genomics, Center for Integrated Oncology Köln Bonn, University of Cologne, Cologne, Germany; §Lung Cancer Group Cologne, Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany; ‖Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany; ¶Center for Integrated Oncology Köln Bonn, Institute of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany; and #Institute of Hematopathology Hamburg, Hamburg, Germany.
Merkelbach-Bruse S
Bos M
Fassunke J
Gardizi M
Michels S
Groneck L
Schultheis AM
Malchers F
Leenders F
Kobe C
König K
Heukamp LC
Sos ML
Thomas RK
Büttner R
Wolf J
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Źródło :
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2015 Jun; Vol. 10 (6), pp. e40-3.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
ErbB Receptors/*antagonists & inhibitors
Lung Neoplasms/*drug therapy
Lung Neoplasms/*genetics
Proto-Oncogene Proteins c-met/*genetics
Drug Resistance, Neoplasm ; Gene Amplification ; Humans ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Mutation ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Implementation of Amplicon Parallel Sequencing Leads to Improvement of Diagnosis and Therapy of Lung Cancer Patients.
Autorzy :
König K; Institute of Pathology, University Hospital of Cologne, Cologne, Germany; †Center for Integrated Oncology Cologne/Bonn, University Hospital of Cologne, Cologne, Germany; ‡Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; §Labor Dr. Quade und Kollegen GmbH, Cologne, Germany; ‖Institute of Human Genetics, University of Cologne, Cologne, Germany; ¶Targos Molecular Pathology GmbH, Kassel, Germany; #Department of Translational Genomics, University of Cologne, Cologne, Germany; **Cologne Center for Genomics, Cologne, Germany; ††GENterprise GENOMICS GmbH, Mainz, Germany; ‡‡Bristol-Myers Squibb R&D, Princeton, New Jersey; §§Evangelische Kliniken Johanniter, Bonn, Germany; ‖‖Malteser Krankenhaus, Lung Cancer Center, Bonn, Germany; ¶¶Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; ##Institute for Hematopathology Hamburg, Hamburg, Germany; and ***New Oncology, Cologne, Germany.
Peifer M
Fassunke J
Ihle MA
Künstlinger H
Heydt C
Stamm K
Ueckeroth F
Vollbrecht C
Bos M
Gardizi M
Scheffler M
Nogova L
Leenders F
Albus K
Meder L
Becker K
Florin A
Rommerscheidt-Fuss U
Altmüller J
Kloth M
Nürnberg P
Henkel T
Bikár SE
Sos ML
Geese WJ
Strauss L
Ko YD
Gerigk U
Odenthal M
Zander T
Wolf J
Merkelbach-Bruse S
Buettner R
Heukamp LC
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Źródło :
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2015 Jul; Vol. 10 (7), pp. 1049-57.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinoma, Non-Small-Cell Lung/*genetics
Carcinoma, Non-Small-Cell Lung/*therapy
Lung Neoplasms/*genetics
Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Cohort Studies ; DNA, Neoplasm/analysis ; DNA, Neoplasm/genetics ; DNA, Neoplasm/isolation & purification ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/therapy ; Polymerase Chain Reaction/methods ; Sequence Analysis, DNA/methods
Czasopismo naukowe
Tytuł :
Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients.
Autorzy :
Michels S; Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany.
Scheel AH; Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Scheffler M; Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany.
Schultheis AM; Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Gautschi O; Department for Medical Oncology, Lucerne Cantonal Hospital, Lucerne, Switzerland.
Aebersold F; Institute of Pathology, Lucerne Cantonal Hospital, Lucerne, Switzerland.
Diebold J; Institute of Pathology, Lucerne Cantonal Hospital, Lucerne, Switzerland.
Pall G; Department for Internal Medicine, Haematology and Oncology, University Hospital Innsbruck, Innsbruck, Austria.
Rothschild S; Department for Oncology, University Hospital Basel, Basel, Switzerland.
Bubendorf L; Department for Cytopathology, University Hospital Basel, Basel, Switzerland.
Hartmann W; Gerhard-Domagk-Institute of Pathology, University Hospital of Münster, Münster, Germany.
Heukamp L; Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Schildhaus HU; Institute of Pathology, University Hospital of Göttigen, Göttingen, Germany.
Fassunke J; Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Ihle MA; Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Künstlinger H; Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Heydt C; Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Fischer R; Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany.
Nogovà L; Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany.
Mattonet C; Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany.
Hein R; Institute of Medical Statistics, Informatics and Epidemiology, University Hospital of Cologne, Cologne, Germany.
Adams A; Institute of Medical Statistics, Informatics and Epidemiology, University Hospital of Cologne, Cologne, Germany.
Gerigk U; Thoracic Centre, Malteser Hospital Bonn/Rhein-Sieg, Bonn, Germany.
Schulte W; Departent for Pulmonology Cardiology and Allergology, Johanniter Hospital, Bonn, Germany.
Lüders H; Evangelic Lung Clinic Berlin, Department of Pneumology, Berlin, Germany.
Grohé C; Evangelic Lung Clinic Berlin, Department of Pneumology, Berlin, Germany.
Graeven U; Department for Hematology, Oncology and Gastroenterology, Maria Hilf Hospital Mönchengladbach, Mönchengladbach, Germany.
Müller-Naendrup C; Private Practice for Oncology, Medical Centre II (Martinus Höfe), Olpe, Germany.
Draube A; Department for Internal Medicine, St. Vinzenz Hospital Cologne, Cologne, Germany.
Kambartel KO; Department for Pulmonology and Allergology, Bethanien Hospital Moers, Moers, Germany.
Krüger S; Department for Pulmonology/Allergology/Sleep Medicine and Respiratory Care, Florence-Nightingale-Hospital, Düsseldorf, Germany.
Schulze-Olden S; Department for Pulmonology/Allergology/Sleep Medicine and Respiratory Care, Florence-Nightingale-Hospital, Düsseldorf, Germany.
Serke M; Department for Pulmonology and Thoracic Oncology, Lung Clinic Hemer, Hemer, Germany.
Engel-Riedel W; Lung Clinic Merheim, Hospitals of Cologne, Cologne, Germany.
Kaminsky B; Clinic for Pulmonology and Allergology, Bethanien Hospital, Solingen, Germany.
Randerath W; Clinic for Pulmonology and Allergology, Bethanien Hospital, Solingen, Germany.
Merkelbach-Bruse S; Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Büttner R; Network Genomic Medicine, Cologne, Germany; Institute of Pathology, University Hospital of Cologne, Cologne, Germany.
Wolf J; Center for Integrated Oncology Köln Bonn, Cologne, Germany; Lung Cancer Group Cologne, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Network Genomic Medicine, Cologne, Germany. Electronic address: .
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Źródło :
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2016 Jan; Vol. 11 (1), pp. 122-7.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Rearrangement*
Adenocarcinoma/*genetics
Biomarkers, Tumor/*genetics
Carcinoma, Squamous Cell/*genetics
Lung Neoplasms/*genetics
Proto-Oncogene Proteins c-ret/*genetics
Adenocarcinoma/pathology ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/pathology ; Europe ; Female ; Follow-Up Studies ; Humans ; In Situ Hybridization, Fluorescence ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Neoplasm Staging ; Oncogene Proteins, Fusion/genetics ; Prognosis ; Retrospective Studies
Czasopismo naukowe
Tytuł :
Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors.
Autorzy :
Ortiz-Cuaran S; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.
Scheffler M; Department I of Internal Medicine, Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Cologne, Germany.
Plenker D; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany. Molecular Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany.
Dahmen L; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.
Scheel AH; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany.
Fernandez-Cuesta L; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany. Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO), Lyon, France.
Meder L; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany.
Lovly CM; Department of Medicine, Vanderbilt University, Nashville, Tennessee.
Persigehl T; Radiology Department, University Hospital Cologne, Cologne, Germany.
Merkelbach-Bruse S; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany.
Bos M; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.
Michels S; Department I of Internal Medicine, Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Cologne, Germany.
Fischer R; Department I of Internal Medicine, Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Cologne, Germany.
Albus K; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany.
König K; Labor Dr. Quade und Kollegen GmbH, Cologne, Germany.
Schildhaus HU; Institute of Pathology, University Hospital Goettingen, Goettingen, Germany.
Fassunke J; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany.
Ihle MA; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany.
Pasternack H; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany. Pathology of the University Hospital of Luebeck and Leibniz Research Center Borstel, Lübeck and Borstel, Germany.
Heydt C; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany.
Becker C; Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany.
Altmüller J; Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany.
Ji H; Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, China. School of Life Science and Technology, Shanghai Tech University, Shanghai, China.
Müller C; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.
Florin A; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany.
Heuckmann JM; NEO New Oncology AG, Cologne, Germany.
Nuernberg P; Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany.
Ansén S; Department I of Internal Medicine, Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Cologne, Germany.
Heukamp LC; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany. NEO New Oncology AG, Cologne, Germany.
Berg J; Institute for Theoretical Physics. University of Cologne, Cologne, Germany.
Pao W; Department of Medicine, Vanderbilt University, Nashville, Tennessee.
Peifer M; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Buettner R; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany. .
Wolf J; Department I of Internal Medicine, Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Cologne, Germany. .
Thomas RK; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany. Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany. .
Sos ML; Molecular Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany. .
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Źródło :
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2016 Oct 01; Vol. 22 (19), pp. 4837-4847. Date of Electronic Publication: 2016 Jun 01.
Typ publikacji :
Journal Article
MeSH Terms :
Adenocarcinoma/*drug therapy
Antineoplastic Agents/*therapeutic use
Drug Resistance, Neoplasm/*genetics
Lung Neoplasms/*drug therapy
Acrylamides/therapeutic use ; Adenocarcinoma of Lung ; Aged ; Aniline Compounds/therapeutic use ; ErbB Receptors/antagonists & inhibitors ; Female ; Humans ; Male ; Middle Aged ; Pyrimidines/therapeutic use
Czasopismo naukowe
Tytuł :
P2.03b-028 Improved Overall Survival Following Implementation of NGS in Routine Diagnostics of Advanced Lung Cancer in Germany: Results of the NGM: Topic: Biomarkers
Autorzy :
Kostenko, Anna
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Źródło :
In Journal of Thoracic Oncology January 2017 12(1) Supplement:S950-S951
Czasopismo naukowe

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